DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SCF_FBW7_1

Location: 1276:1283

E3 ligase: FBXW7

DEGRON score: 0.9661

ASA_SCORE: 82.825

COIL: 0.9578

CONS_SCORE: 0.2847

DSS_SCORE: 0.5788

HELIX: 0.0133

FCONS_SCORE: 1.0124

RIG_SCORE: 0.5914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1290R	TCGA-BR-6452	STAD	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	0.1389
p.S1290R	DO38404	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.1389
p.L1289I	TCGA-CG-4460	STAD	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	0.1667
p.L1289I	DO38427	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.1667
p.S1281R	TCGA-CG-5733	STAD	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	0.6316
p.S1281R	DO38551	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.6316
p.S1278L	TCGA-EE-A2A1	SKCM	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	0.6556
p.S1278L	DO38045	SKCM	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.6556
p.P1284L	DO48423	BLCA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.3056
p.P1272L	DO4611	BRCA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.2222
p.P1272L	DO38192	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.2222
p.T1285M	DO227984	COCA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.2778
p.A1285S	DO229045	LICA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	0.2778
p.P1292S	SIDM00140	Melanoma	GDSC	PSSTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1292S	ACH-000968	Skin Cancer	CCLE	PSSTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1292S	COLO-792	skin	COSMIC	PSSTPSTT	DEG_SCF_FBW7_1	0.0833
p.S1290G	SIDM01594	Breast Carcinoma	GDSC	PSSTPSTT	DEG_SCF_FBW7_1	0.1389
p.T1281A	JHH-4	liver	COSMIC	PSSTPSTT	DEG_SCF_FBW7_1	0.7139
p.V1289L	SK-MEL-24	skin	COSMIC	PSSTPSTT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SCF_FBW7_1	1276:1283	PSSTPSTT	FBXW7	0.9661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons