DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SIAH_1

Location: 1478:1486

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9758

ASA_SCORE: 90.7889

COIL: 0.9462

CONS_SCORE: 0.3011

DSS_SCORE: 0.3792

HELIX: 0.011

FCONS_SCORE: 1.2179

RIG_SCORE: 0.7031

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1485S	DO44437	HNSC	ICGC	PPLAPVVPA	DEG_SIAH_1	0.6752
p.P1478L	DO220912	MELA	ICGC	PPLAPVVPA	DEG_SIAH_1	0.6471
p.P1473L	DO38063	SKCM	ICGC	PPLAPVVPA	DEG_SIAH_1	0.1944
p.S1468L	SIDM00371	Pancreatic Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00157	Neuroblastoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00569	Osteosarcoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00687	Gastric Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00245	Small Cell Lung Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM01210	Glioblastoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00616	Hepatocellular Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM01412	Oral Cavity Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM01494	Glioblastoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM01321	Pancreatic Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SIDM01443	Gastric Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	KNS-81-FD	central_nervous_system	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	JHH-4	liver	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	KP-N-YS	autonomic_ganglia	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	SUIT-2	pancreas	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	NY	bone	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	MS-1	lung	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	PC-3_[JPC-3]	lung	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556
p.S1468L	KATOIII	stomach	COSMIC	PPLAPVVPA	DEG_SIAH_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLAPVVPA

Degron related mutations and impact score

Drug responses associated with SRCAP mutations

All proteins holding degron of PPLAPVVPA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SIAH_1	1478:1486	PPLAPVVPA	SIAH1,SIAH2,SIAH3	0.9758	More...