DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_COP1_1

Location: 2215:2225

E3 ligase: COP1

DEGRON score: 0.9626

ASA_SCORE: 81.5091

COIL: 0.9314

CONS_SCORE: 0.3258

DSS_SCORE: 0.7242

HELIX: 0.0467

FCONS_SCORE: 0.7679

RIG_SCORE: 0.5889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2227K	TCGA-CV-7242	HNSC	TCGA	EEPSSSSVPSA	DEG_COP1_1	0.2778
p.E2227K	TCGA-XF-AAMZ	BLCA	TCGA	EEPSSSSVPSA	DEG_COP1_1	0.2778
p.E2227K	DO219051	BLCA	ICGC	EEPSSSSVPSA	DEG_COP1_1	0.2778
p.E2227K	DO14974	HNSC	ICGC	EEPSSSSVPSA	DEG_COP1_1	0.2778
p.S2220L	TCGA-EE-A2MR	SKCM	TCGA	EEPSSSSVPSA	DEG_COP1_1	0.6556
p.A2234S	TCGA-IB-7651	PAAD	TCGA	EEPSSSSVPSA	DEG_COP1_1	0.0833
p.D2211H	TCGA-VS-A9UZ	CESC	TCGA	EEPSSSSVPSA	DEG_COP1_1	0.2222
p.A2223S	DO229019	LICA	ICGC	EEPSSSSVPSA	DEG_COP1_1	0.7588
p.E2208D	DO229035	LICA	ICGC	EEPSSSSVPSA	DEG_COP1_1	0.1389
p.R2235W	DO26250	LUAD	ICGC	EEPSSSSVPSA	DEG_COP1_1	0.0556
p.T2205A	SIDM02026	Colorectal Carcinoma	GDSC	EEPSSSSVPSA	DEG_COP1_1	0.0556
p.E2230V	SIDM01261	Breast Carcinoma	GDSC	EEPSSSSVPSA	DEG_COP1_1	0.1944
p.E2230V	YMB-1-E	breast	COSMIC	EEPSSSSVPSA	DEG_COP1_1	0.1944
p.P2226L	ACH-001063	Ovarian Cancer	CCLE	EEPSSSSVPSA	DEG_COP1_1	0.3056
p.P2226S	Mewo	skin	COSMIC	EEPSSSSVPSA	DEG_COP1_1	0.3056
p.P2228A	CHP-134	autonomic_ganglia	COSMIC	EEPSSSSVPSA	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_COP1_1	2215:2225	EEPSSSSVPSA	COP1	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons