DegronMD - Q9H2Y9(SLCO5A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P835S	TCGA-17-Z055	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.25
p.G75C	TCGA-44-5644	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0556
p.G75C	DO8264	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0556
p.G75C	DO25153	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0556
p.N77K	TCGA-75-6214	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1111
p.N77K	DO24830	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1111
p.S89L	TCGA-86-A4JF	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7667
p.S89L	TCGA-AA-3977	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7667
p.S89L	TCGA-CA-6717	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7667
p.S89L	DO8730	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7667
p.S89L	DO8264	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7667
p.S89L	DO45317	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7667
p.R98M	TCGA-A5-A0G2	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.R98M	DO41235	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.S832Y	TCGA-B7-A5TI	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation altering degron motif	0.712
p.E839G	TCGA-BH-A0AZ	BRCA	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.1389
p.A842T	TCGA-BR-4361	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.0556
p.P78A	TCGA-CN-6012	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.P78A	DO15743	HNSC	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.A833V	TCGA-D5-6540	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.3056
p.A833V	SIDM00781	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.3056
p.A833V	SIDM00780	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.3056
p.A833V	ACH-000967	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.3056
p.A833V	ACH-001199	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.3056
p.A833V	SNU-C2B	large intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.3056
p.P822S	TCGA-EE-A2GC	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.1667
p.P824S	TCGA-EE-A2GM	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.2222
p.P826L	TCGA-EE-A3AG	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.2778
p.A90V	TCGA-IB-7651	PAAD	TCGA	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.A90V	DO233888	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.A90V	DO46657	PAAD	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.D834N	TCGA-YD-A89C	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.2778
p.A90T	DO228769	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.T88S	DO233650	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.6005
p.G75D	DO233898	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0556
p.L92H	DO46394	OV	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.25
p.G93W	DO32819	PACA	ICGC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.G93W	SIDM01136	Pancreatic Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.G93W	ACH-000417	Pancreatic Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.G93W	PANC-08-13	pancreas	COSMIC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.P78R	SIDM01265	Plasma Cell Myeloma	GDSC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.P78R	SIDM00393	Gastric Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.S840N	SIDM01248	Thyroid Gland Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.1111
p.S840N	ACH-001023	Thyroid Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.1111
p.S840N	CGTH-W-1	thyroid	COSMIC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.1111
p.F825L	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.25
p.F825L	ACH-002393	Lymphoma	CCLE	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.25
p.F825L	CRO-AP3	NS	COSMIC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation rewiring degron network	0.25
p.G75S	ACH-000591	Brain Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0556
p.S831P	ACH-000937	Leukemia	CCLE	AISSS	DEG_SPOP_SBC_1	828:832	Mutation altering degron motif	0.6752
p.S831P	PF-382	haematopoietic and lymphoid tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	828:832	Mutation altering degron motif	0.6752
p.P81L	ACH-002508	Skin Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLCO5A1

UniProt ID: Q9H2Y9

Entrez ID: 81796

Protein name: Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLCO5A1 in