DegronMD

Uniprot ID: Q9H2Y9

Source protein: Solute carrier organic anion transporter family member 5A1

Source gene: SLCO5A1

Class: DEG_SPOP_SBC_1

Location: 828:832

E3 ligase: SPOP

DEGRON score: 0.9696

ASA_SCORE: 65.66

COIL: 0.7644

CONS_SCORE: 0.3307

DSS_SCORE: 0.7099

HELIX: 0.0542

FCONS_SCORE: 1.0403

RIG_SCORE: 0.6494

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S832Y	TCGA-B7-A5TI	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.712
p.S831P	ACH-000937	Leukemia	CCLE	AISSS	DEG_SPOP_SBC_1	0.6752
p.S831P	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	0.6752
p.A833V	TCGA-D5-6540	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.3056
p.A833V	SIDM00781	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.3056
p.A833V	SIDM00780	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.3056
p.A833V	ACH-000967	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.3056
p.A833V	ACH-001199	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.3056
p.A833V	SNU-C2B	large_intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	0.3056
p.P826L	TCGA-EE-A3AG	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.2778
p.D834N	TCGA-YD-A89C	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.2778
p.P835S	TCGA-17-Z055	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.25
p.F825L	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.25
p.F825L	ACH-002393	Lymphoma	CCLE	AISSS	DEG_SPOP_SBC_1	0.25
p.F825L	CRO-AP3	NS	COSMIC	AISSS	DEG_SPOP_SBC_1	0.25
p.P824S	TCGA-EE-A2GM	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.2222
p.P822S	TCGA-EE-A2GC	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.1667
p.E839G	TCGA-BH-A0AZ	BRCA	TCGA	AISSS	DEG_SPOP_SBC_1	0.1389
p.S840N	SIDM01248	Thyroid Gland Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.1111
p.S840N	ACH-001023	Thyroid Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.1111
p.S840N	CGTH-W-1	thyroid	COSMIC	AISSS	DEG_SPOP_SBC_1	0.1111
p.A842T	TCGA-BR-4361	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 22 of 22 entries

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Drug responses associated with SLCO5A1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AISSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	385:389	AISSS	SPOP	0.9915	More...
Q8IV76	Circadian clock protein PASD1	DEG_SPOP_SBC_1	663:667	AISSS	SPOP	0.9769	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	DEG_SPOP_SBC_1	423:427	AISSS	SPOP	0.9739	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	346:350	AISSS	SPOP	0.7859	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	514:518	AISSS	SPOP	0.9574	More...
Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	DEG_SPOP_SBC_1	452:456	AISSS	SPOP	0.9867	More...
Q7Z7G1	Cytokine-dependent hematopoietic cell linker	DEG_SPOP_SBC_1	241:245	AISSS	SPOP	0.99	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9325:9329	AISSS	SPOP	0.9855	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3731:3735	AISSS	SPOP	0.789	More...
Q5VWP3	Muscular LMNA-interacting protein	DEG_SPOP_SBC_1	165:169	AISSS	SPOP	0.9764	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	121:125	AISSS	SPOP	0.925	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	80:84	AISSS	SPOP	0.9244	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	515:519	AISSS	SPOP	0.8539	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	828:832	AISSS	SPOP	0.9696	More...
Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	DEG_SPOP_SBC_1	494:498	AISSS	SPOP	0.9795	More...
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	673:677	AISSS	SPOP	0.5288	More...

Showing 1 to 16 of 16 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISSS

Degron related mutations and impact score

Drug responses associated with SLCO5A1 mutations

All proteins holding degron of AISSS