DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AISSS
Uniprot ID:
Q3SYA9
Source protein:
Putative POM121-like protein 1
Source gene:
POM121L1P
Class:
DEG_SPOP_SBC_1
Location:
121:125
E3 ligase:
SPOP
DEGRON score:
0.925
ASA_SCORE:
47.6
COIL:
0.7508
CONS_SCORE:
0
DSS_SCORE:
0.471
HELIX:
0.0826
FCONS_SCORE:
0
RIG_SCORE:
0.6813
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121L1P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AISSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P17948
Vascular endothelial growth factor receptor 1
DEG_SPOP_SBC_1
673:677
AISSS
SPOP
0.5288
More...
P55199
RNA polymerase II elongation factor ELL
DEG_SPOP_SBC_1
515:519
AISSS
SPOP
0.8539
More...
Q16630
Cleavage and polyadenylation specificity factor subunit 6
DEG_SPOP_SBC_1
423:427
AISSS
SPOP
0.9739
More...
Q5VWP3
Muscular LMNA-interacting protein
DEG_SPOP_SBC_1
165:169
AISSS
SPOP
0.9764
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3731:3735
AISSS
SPOP
0.789
More...
Q6UUV9
CREB-regulated transcription coactivator 1
DEG_SPOP_SBC_1
514:518
AISSS
SPOP
0.9574
More...
Q6VMQ6
Activating transcription factor 7-interacting protein 1
DEG_SPOP_SBC_1
385:389
AISSS
SPOP
0.9915
More...
Q7Z7G1
Cytokine-dependent hematopoietic cell linker
DEG_SPOP_SBC_1
241:245
AISSS
SPOP
0.99
More...
Q8IV76
Circadian clock protein PASD1
DEG_SPOP_SBC_1
663:667
AISSS
SPOP
0.9769
More...
Q8IYJ2
Uncharacterized protein C10orf67, mitochondrial
DEG_SPOP_SBC_1
494:498
AISSS
SPOP
0.9795
More...
Q8N684
Cleavage and polyadenylation specificity factor subunit 7
DEG_SPOP_SBC_1
346:350
AISSS
SPOP
0.7859
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
9325:9329
AISSS
SPOP
0.9855
More...
Q9Y222
Cyclin-D-binding Myb-like transcription factor 1
DEG_SPOP_SBC_1
452:456
AISSS
SPOP
0.9867
More...
Q9H2Y9
Solute carrier organic anion transporter family member 5A1
DEG_SPOP_SBC_1
828:832
AISSS
SPOP
0.9696
More...
A6NNC1
Putative POM121-like protein 1-like
DEG_SPOP_SBC_1
80:84
AISSS
SPOP
0.9244
More...
Q3SYA9
Putative POM121-like protein 1
DEG_SPOP_SBC_1
121:125
AISSS
SPOP
0.925
More...