DegronMD

Uniprot ID: P17948

Source protein: Vascular endothelial growth factor receptor 1

Source gene: FLT1

Class: DEG_SPOP_SBC_1

Location: 673:677

E3 ligase: SPOP

DEGRON score: 0.5288

ASA_SCORE: 57.2

COIL: 0.512

CONS_SCORE: 0.3624

DSS_SCORE: 0.307

HELIX: 0.0434

FCONS_SCORE: 0.7702

RIG_SCORE: 0.7244

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S668C	TCGA-77-8156	LUSC	TCGA	AISSS	DEG_SPOP_SBC_1	0.1944
p.S668C	DO26802	LUSC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1944
p.D681Y	TCGA-AG-A002	READ	TCGA	AISSS	DEG_SPOP_SBC_1	0.2222
p.S677A	TCGA-BR-6452	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.7588
p.S677A	DO38404	STAD	ICGC	AISSS	DEG_SPOP_SBC_1	0.7588
p.N666I	TCGA-CC-A9FU	LIHC	TCGA	AISSS	DEG_SPOP_SBC_1	0.1389
p.N666I	DO52190	LIHC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1389
p.T679N	TCGA-CV-7178	HNSC	TCGA	AISSS	DEG_SPOP_SBC_1	0.2778
p.T679N	DO14774	HNSC	ICGC	AISSS	DEG_SPOP_SBC_1	0.2778
p.A673T	TCGA-CV-7424	HNSC	TCGA	AISSS	DEG_SPOP_SBC_1	0.7139
p.A673T	TCGA-D7-A4Z0	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.7139
p.A673T	DO14998	HNSC	ICGC	AISSS	DEG_SPOP_SBC_1	0.7139
p.A673T	DO47765	STAD	ICGC	AISSS	DEG_SPOP_SBC_1	0.7139
p.H670Y	TCGA-D3-A3C1	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.25
p.H670Y	DO47323	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.G686S	TCGA-Z2-A8RT	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.0833
p.G686S	DO51301	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.0833
p.R665Q	DO229344	BTCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1111
p.S675R	DO228952	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	0.7427
p.H683N	DO229028	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.T678N	DO229027	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.A684D	DO229035	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1389
p.A664V	SIDM01307	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.0833
p.A673V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	0.5825
p.A673V	SIDM00238	Ovarian Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.5825
p.A673V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	0.5825
p.A673V	ACH-000947	Ovarian Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.5825
p.A673V	ACH-000995	Leukemia	CCLE	AISSS	DEG_SPOP_SBC_1	0.5825
p.A673V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	0.5825
p.A673V	OVK-18	ovary	COSMIC	AISSS	DEG_SPOP_SBC_1	0.5825
p.T675R	SIDM01186	Breast Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7876
p.T675R	UACC-893	breast	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7876
p.K663N	SIDM01611	Endometrial Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.0556
p.S677F	ACH-001035	Bone Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.7982

Drug responses associated with FLT1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Midostaurin	0.4665
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Cabozantinib	54.4797
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Linifanib	4.1781
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Tivozanib	2.0097
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Cediranib	81.07
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Midostaurin	0.9871
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Cabozantinib	4.964
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Linifanib	6.3378
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Tivozanib	0.2649
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Cediranib	5.6412
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Midostaurin	2.2885
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Cabozantinib	6.7173
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Linifanib	11.0972
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Tivozanib	1.3668
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Cediranib	6.5884
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Midostaurin	0.6754
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Cabozantinib	74.3509
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Linifanib	12.5688
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Tivozanib	1.5352
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Cediranib	3.5062
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Midostaurin	0.2602
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Cabozantinib	17.394
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Linifanib	10.1914
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Tivozanib	1.4202
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Cediranib	6.0808
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Midostaurin	0.1558
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Cabozantinib	13.4877
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Linifanib	8.8383
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Tivozanib	1.39
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Cediranib	5.736
SIDM00981	DLBC\|B_cell_lymphoma	p.S1277N (No)	GDSC	Midostaurin	0.7545
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Midostaurin	0.9804
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Cabozantinib	17.0263
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Linifanib	27.0999
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Tivozanib	2.2397
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Cediranib	4.8151
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Midostaurin	5.707
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Linifanib	5.6349
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Tivozanib	1.1711
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Cediranib	8.4465
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Midostaurin	6.4387
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Cabozantinib	33.5864
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Linifanib	8.2605
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Tivozanib	2.431
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Cediranib	13.538
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Midostaurin	0.6714
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Cabozantinib	25.621
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Linifanib	11.8566
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Tivozanib	2.5587
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Midostaurin	1.5394
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Cabozantinib	9.767
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Linifanib	12.4528
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Tivozanib	1.4308
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Cediranib	5.3843
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Midostaurin	0.175
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Cabozantinib	14.3579
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Linifanib	9.6552
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Tivozanib	0.8847
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R1257H (No)	GDSC	Cediranib	1.5274
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Midostaurin	0.6669
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Cabozantinib	36.3311
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Linifanib	8.2801
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Tivozanib	0.5535
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Cediranib	4.4919
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Midostaurin	4.472
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Cabozantinib	5.8082
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Linifanib	17.9385
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Tivozanib	1.3661
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Cediranib	6.3731
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Midostaurin	0.8548
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Cabozantinib	4.9456
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Linifanib	2.1076
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Tivozanib	0.2813
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Cediranib	5.8297
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Midostaurin	0.6198
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Cabozantinib	27.0342
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Linifanib	9.9664
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Tivozanib	1.4206
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Cediranib	5.3205
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Midostaurin	0.2459
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Cabozantinib	5.8396
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Linifanib	6.4301
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Tivozanib	1.6521
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Cediranib	2.7741
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Midostaurin	0.2189
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Cabozantinib	4.7936
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Linifanib	10.191
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Tivozanib	1.2085
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Cediranib	8.8365
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Midostaurin	0.6331
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Cabozantinib	52.6341
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Linifanib	12.797
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Tivozanib	1.735
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Cediranib	8.9193
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Midostaurin	0.7932
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Cabozantinib	42.0625
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Linifanib	10.7273
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Tivozanib	1.4343
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Cediranib	5.4692
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Midostaurin	1.3786
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Linifanib	3.4172
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Tivozanib	1.0502
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Cediranib	2.9341
SIDM00687	STAD\|stomach	p.Q1243K (No)	GDSC	Cediranib	0.6944
SIDM00217	COREAD\|large_intestine	p.R183H (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.R183H (No)	GDSC	Linifanib	18.1376
SIDM00217	COREAD\|large_intestine	p.R183H (No)	GDSC	Tivozanib	2.681
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Midostaurin	0.2177
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Cabozantinib	14.1681
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Linifanib	13.9475
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Tivozanib	0.9517
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Cediranib	7.1641
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Midostaurin	1.4879
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Cabozantinib	13.9018
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Linifanib	13.2855
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Tivozanib	1.0314
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Cediranib	11.404
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Midostaurin	0.3009
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Cabozantinib	32.0867
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Linifanib	9.9063
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Tivozanib	0.7059
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Cediranib	10.273
SIDM01147	STAD\|stomach	p.S752L (No)	GDSC	Cediranib	30.809
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Midostaurin	0.2332
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Cabozantinib	7.227
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Linifanib	5.9157
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Tivozanib	0.7436
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Cediranib	6.4073
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Midostaurin	1.6137
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Cabozantinib	37.461
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Linifanib	11.3311
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Tivozanib	1.5913
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Cediranib	28.435
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Midostaurin	0.2969
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Cabozantinib	8.2222
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Linifanib	4.2589
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Tivozanib	0.7205
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Cediranib	3.5639
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Midostaurin	1.2938
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Cabozantinib	2.7944
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Linifanib	7.9397
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Tivozanib	0.1867
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Cediranib	4.0338
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Midostaurin	0.4118
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Cabozantinib	34.719
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Linifanib	13.547
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Tivozanib	1.7085
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Midostaurin	3.3946
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Cabozantinib	215.4655
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Linifanib	41.3801
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Tivozanib	4.3501
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Cediranib	138.91
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Midostaurin	4.6295
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Cabozantinib	40.284
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Linifanib	12.6652
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Tivozanib	1.7957
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Cediranib	2.6753
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Midostaurin	12.6442
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Cabozantinib	55.7164
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Linifanib	26.1518
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Tivozanib	2.4116
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Cediranib	11.404
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Midostaurin	0.4307
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Cabozantinib	19.7098
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Linifanib	6.0444
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Tivozanib	2.0587
SIDM00217	COREAD\|large_intestine	p.M566fs*8 (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.M566fs*8 (No)	GDSC	Linifanib	18.1376
SIDM00217	COREAD\|large_intestine	p.M566fs*8 (No)	GDSC	Tivozanib	2.681
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (No)	GDSC	Midostaurin	0.4196
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (No)	GDSC	Cabozantinib	4.8655
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (No)	GDSC	Linifanib	11.8845
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (No)	GDSC	Tivozanib	1.2883
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (No)	GDSC	Cediranib	2.9029
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Midostaurin	2.816
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Cabozantinib	34.3229
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Linifanib	14.0756
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Tivozanib	1.0736
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Cediranib	4.877
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Midostaurin	6.5133
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Linifanib	18.6537
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Tivozanib	2.2473
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Cediranib	9.5587
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Midostaurin	6.5133
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Linifanib	18.6537
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Tivozanib	2.2473
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Cediranib	9.5587
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Midostaurin	6.5133
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Linifanib	18.6537
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Tivozanib	2.2473
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Cediranib	9.5587
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Midostaurin	0.1437
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Cabozantinib	46.186
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Linifanib	18.5427
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Tivozanib	2.3183
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Cediranib	3.9128
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Midostaurin	0.5691
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Cabozantinib	36.0912
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Linifanib	3.4786
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Tivozanib	0.877
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Midostaurin	0.5968
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Cabozantinib	19.4136
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Linifanib	10.6073
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Tivozanib	1.5361
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Cediranib	25.996
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Midostaurin	1.8701
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Cabozantinib	4.5532
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Linifanib	10.0417
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Tivozanib	2.2374
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Cediranib	93.26
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Midostaurin	1.8701
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Cabozantinib	4.5532
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Linifanib	10.0417
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Tivozanib	2.2374
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Cediranib	93.26
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Midostaurin	0.6542
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Cabozantinib	6.6108
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Linifanib	13.4172
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Tivozanib	1.6768
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Cediranib	5.1694
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Midostaurin	0.331
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Cabozantinib	63.4851
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Linifanib	15.3008
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Tivozanib	2.0611
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Cediranib	86.136
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Midostaurin	14.6277
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Cabozantinib	374.684
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Linifanib	52.4861
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Tivozanib	8.7495
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Cediranib	10.369
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Midostaurin	1.677
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Cabozantinib	79.8364
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Linifanib	16.1299
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Tivozanib	2.0243
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Cediranib	2.468
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Midostaurin	0.3184
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Cabozantinib	51.1254
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Linifanib	24.6252
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Tivozanib	2.5741
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Cediranib	18.416
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Midostaurin	3.1483
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Cabozantinib	65.8693
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Linifanib	20.7769
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Tivozanib	2.5628
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Cediranib	66.142
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Midostaurin	0.3676
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Cabozantinib	18.8192
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Linifanib	9.1717
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Tivozanib	1.8907
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Cediranib	24.911
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Midostaurin	7.5497
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Cabozantinib	267.6604
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Linifanib	32.0276
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Tivozanib	6.3583
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Cediranib	191.15
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Midostaurin	0.1551
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Cabozantinib	10.026
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Linifanib	0.4296
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Tivozanib	1.8145
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Cediranib	2.8576
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Midostaurin	0.7932
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Cabozantinib	42.0625
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Linifanib	10.7273
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Tivozanib	1.4343
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Cediranib	5.4692
SIDM00238	OV\|ovary	p.A673V (Yes)	GDSC	Cabozantinib	99.6708
SIDM00238	OV\|ovary	p.A673V (Yes)	GDSC	Linifanib	17.4035
SIDM00238	OV\|ovary	p.A673V (Yes)	GDSC	Tivozanib	2.6511
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Midostaurin	0.9826
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Cabozantinib	7.319
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Linifanib	15.6177
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Tivozanib	1.0384
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Cediranib	4.6927
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Midostaurin	9.6608
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Cabozantinib	3.1184
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Linifanib	16.0025
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Tivozanib	2.0618
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Cediranib	1.7237
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Midostaurin	1.7165
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Cabozantinib	32.8868
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Linifanib	8.1207
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Tivozanib	1.8598
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Cediranib	147.05
SIDM00193	COREAD\|large_intestine	p.V721A (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.V721A (No)	GDSC	Linifanib	15.5526
SIDM00193	COREAD\|large_intestine	p.V721A (No)	GDSC	Tivozanib	1.8904
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Midostaurin	2.9471
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Linifanib	12.9878
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Tivozanib	1.6445
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Cediranib	5.8015
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Midostaurin	2.9471
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Linifanib	12.9878
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Tivozanib	1.6445
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Cediranib	5.8015

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	673:677	AISSS	SPOP	0.5288	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	515:519	AISSS	SPOP	0.8539	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	DEG_SPOP_SBC_1	423:427	AISSS	SPOP	0.9739	More...
Q5VWP3	Muscular LMNA-interacting protein	DEG_SPOP_SBC_1	165:169	AISSS	SPOP	0.9764	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3731:3735	AISSS	SPOP	0.789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	514:518	AISSS	SPOP	0.9574	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	385:389	AISSS	SPOP	0.9915	More...
Q7Z7G1	Cytokine-dependent hematopoietic cell linker	DEG_SPOP_SBC_1	241:245	AISSS	SPOP	0.99	More...
Q8IV76	Circadian clock protein PASD1	DEG_SPOP_SBC_1	663:667	AISSS	SPOP	0.9769	More...
Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	DEG_SPOP_SBC_1	494:498	AISSS	SPOP	0.9795	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	346:350	AISSS	SPOP	0.7859	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9325:9329	AISSS	SPOP	0.9855	More...
Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	DEG_SPOP_SBC_1	452:456	AISSS	SPOP	0.9867	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	828:832	AISSS	SPOP	0.9696	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	80:84	AISSS	SPOP	0.9244	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	121:125	AISSS	SPOP	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISSS

Degron related mutations and impact score

Drug responses associated with FLT1 mutations

All proteins holding degron of AISSS