DegronMD - Q6UUV9(CRTC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E281K	TCGA-06-5416	GBM	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1667
p.A510V	TCGA-2H-A9GF	ESCA	TCGA	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.A510V	TCGA-ZF-A9RF	BLCA	TCGA	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.L274F	TCGA-B5-A3FC	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.6981
p.G84R	TCGA-BS-A0TJ	UCEC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7568
p.G84R	DO42953	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7568
p.L265M	TCGA-D7-A6EY	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1667
p.G72W	TCGA-EE-A2GT	SKCM	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.P277S	TCGA-EE-A3JD	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2778
p.M313R	TCGA-EO-A3AY	UCEC	TCGA	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.0556
p.E281D	TCGA-EO-A3B0	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1667
p.P271S	TCGA-FS-A1ZQ	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.6752
p.T75I	TCGA-G4-6628	COAD	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.A511T	TCGA-IB-7651	PAAD	TCGA	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.25
p.Q70H	TCGA-Q1-A5R2	CESC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.0833
p.G72R	TCGA-Q1-A73O	CESC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.G72E	TCGA-Q1-A73O	CESC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.S183F	TCGA-QB-AA9O	SKCM	TCGA	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.7982
p.P275L	TCGA-V1-A9OA	PRAD	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7582
p.P275L	SIDM00976	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7582
p.P275L	WM1552C	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7582
p.D264N	TCGA-VS-A8QA	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1389
p.P273L	TCGA-YD-A9TA	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7582
p.L194V	DO223513	BLCA	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.S285L	DO481	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0556
p.S285L	DO222764	ESCA	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0556
p.R76W	DO7997	COAD	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.25
p.T287A	DO230334	COCA	ICGC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.0556
p.T287A	DO225404	LAML	ICGC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.0556
p.R69W	DO228068	EOPC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.0556
p.R69Q	DO233724	GACA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.0556
p.S170F	DO233894	GACA	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.H265Q	DO20778	KIRP	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1667
p.Q283L	DO228827	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1111
p.A193S	DO228952	LICA	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1389
p.G516V	DO229026	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7532
p.A87S	DO229035	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.3056
p.S83I	DO229041	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7341
p.R85W	DO229051	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.8634
p.R85W	SNU-C5	large intestine	COSMIC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.8634
p.V95F	DO229006	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.0833
p.A302T	DO50827	LIRI	ICGC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.7139
p.R280W	DO26890	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1944
p.P310L	DO220859	MELA	ICGC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.1389
p.P504S	DO220875	MELA	ICGC	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.T277A	DO232863	NACA	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2778
p.Q282K	DO233298	NACA	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1389
p.S72P	DO30420	OV	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.S72F	DO49826	PRAD	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.P518H	DO47278	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7694
p.P91L	DO51299	SKCM	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1944
p.P91S	DO51299	SKCM	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1944
p.P196S	DO38123	SKCM	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.0556
p.L273V	DO47973	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.6765
p.A312T	DO229264	THCA	ICGC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation blocking phosphorylation signal	0.5278
p.D88N	DO41020	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2778
p.D88N	DO41379	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2778
p.G71S	DO41686	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1111
p.R75H	DO41871	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.T168M	DO42568	UCEC	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.0556
p.S89I	DO41361	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.25
p.T302M	SIDM01314	Colorectal Carcinoma	GDSC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.7423
p.A298T	SIDM00438	B-Lymphoblastic Leukemia	GDSC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.7139
p.A298T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.7139
p.A298T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.7139
p.A298T	MN-60	haematopoietic and lymphoid tissue	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.7139
p.A287T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.0556
p.A287T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.0556
p.M510V	ACH-000088	Non-Cancerous	CCLE	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.S522N	ACH-000776	Brain Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.S522N	ONS-76	central nervous system	COSMIC	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.S303T	ACH-000792	Kidney Cancer	CCLE	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.6005
p.S303T	BFTC-909	kidney	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.6005
p.A271T	ACH-000874	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7139
p.A271T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7139
p.A282T	ACH-000874	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1389
p.A282T	ACH-002275	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1389
p.A282T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1389
p.A282T	MN-60	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1389
p.G524A	ACH-000997	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.G524A	ACH-001061	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.D196N	ACH-002125	Lung Cancer	CCLE	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.0556
p.D196N	H2461	pleura	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.0556
p.G279S	ACH-002396	Bone Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.G279S	Sarc9371	bone	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.G279D	ACH-002396	Bone Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.G279D	Sarc9371	bone	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.D263N	ACH-002508	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1111
p.G295D	Sarc9371	bone	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.2778
p.S262T	BFTC-909	kidney	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0833
p.S280N	ONS-76	central nervous system	COSMIC	ALSSS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1944
p.A196T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.0556
p.P172S	TE-1	oesophagus	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation blocking phosphorylation signal	0.6111
p.I182V	SNU-1040	large intestine	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.7076
p.G295S	Sarc9371	bone	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.2778
p.P184L	WM1552C	skin	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRTC1

UniProt ID: Q6UUV9

Entrez ID: 23373

Protein name: CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRTC1 in