DegronMD

Uniprot ID: Q6UUV9

Source protein: CREB-regulated transcription coactivator 1

Source gene: CRTC1

Class: DEG_APCC_DBOX_1

Location: 178:186

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6026

ASA_SCORE: 84.5667

COIL: 0.7062

CONS_SCORE: 0.4065

DSS_SCORE: 0.5437

HELIX: 0.195

FCONS_SCORE: 0.9819

RIG_SCORE: 0.797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S183F	TCGA-QB-AA9O	SKCM	TCGA	KRVLLLTVP	DEG_APCC_DBOX_1	0.7982
p.L194V	DO223513	BLCA	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	0.1111
p.S170F	DO233894	GACA	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	0.1111
p.A193S	DO228952	LICA	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	0.1389
p.P196S	DO38123	SKCM	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	0.0556
p.T168M	DO42568	UCEC	ICGC	KRVLLLTVP	DEG_APCC_DBOX_1	0.0556
p.D196N	ACH-002125	Lung Cancer	CCLE	KRVLLLTVP	DEG_APCC_DBOX_1	0.0556
p.D196N	H2461	pleura	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	0.0556
p.A196T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	0.0556
p.P172S	TE-1	oesophagus	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	0.6111
p.I182V	SNU-1040	large_intestine	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	0.7076
p.P184L	WM1552C	skin	COSMIC	KRVLLLTVP	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_APCC_DBOX_1	178:186	KRVLLLTVP	APC,CDC20,FZR1	0.6026	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons