DegronMD

Uniprot ID: Q6UUV9

Source protein: CREB-regulated transcription coactivator 1

Source gene: CRTC1

Class: DEG_SCF_FBW7_1

Location: 297:303

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 69.3286

COIL: 0.9514

CONS_SCORE: 0.4313

DSS_SCORE: 0.7684

HELIX: 0.0109

FCONS_SCORE: 0.9985

RIG_SCORE: 0.518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M313R	TCGA-EO-A3AY	UCEC	TCGA	MSTPGSS	DEG_SCF_FBW7_1	0.0556
p.T287A	DO230334	COCA	ICGC	MSTPGSS	DEG_SCF_FBW7_1	0.0556
p.T287A	DO225404	LAML	ICGC	MSTPGSS	DEG_SCF_FBW7_1	0.0556
p.A302T	DO50827	LIRI	ICGC	MSTPGSS	DEG_SCF_FBW7_1	0.7139
p.P310L	DO220859	MELA	ICGC	MSTPGSS	DEG_SCF_FBW7_1	0.1389
p.A312T	DO229264	THCA	ICGC	MSTPGSS	DEG_SCF_FBW7_1	0.5278
p.T302M	SIDM01314	Colorectal Carcinoma	GDSC	MSTPGSS	DEG_SCF_FBW7_1	0.7423
p.A298T	SIDM00438	B-Lymphoblastic Leukemia	GDSC	MSTPGSS	DEG_SCF_FBW7_1	0.7139
p.A298T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	MSTPGSS	DEG_SCF_FBW7_1	0.7139
p.A298T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	0.7139
p.A298T	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	0.7139
p.A287T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	MSTPGSS	DEG_SCF_FBW7_1	0.0556
p.A287T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	0.0556
p.S303T	ACH-000792	Kidney Cancer	CCLE	MSTPGSS	DEG_SCF_FBW7_1	0.6005
p.S303T	BFTC-909	kidney	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	0.6005
p.G295D	Sarc9371	bone	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	0.2778
p.G295S	Sarc9371	bone	COSMIC	MSTPGSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SCF_FBW7_1	297:303	MSTPGSS	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons