DegronMD

Uniprot ID: Q6UUV9

Source protein: CREB-regulated transcription coactivator 1

Source gene: CRTC1

Class: DEG_SCF_FBW7_1

Location: 79:86

E3 ligase: FBXW7

DEGRON score: 0.9375

ASA_SCORE: 70

COIL: 0.8609

CONS_SCORE: 0.3117

DSS_SCORE: 0.5466

HELIX: 0.0833

FCONS_SCORE: 0.6928

RIG_SCORE: 0.7452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G84R	TCGA-BS-A0TJ	UCEC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	0.7568
p.G84R	DO42953	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.7568
p.G72W	TCGA-EE-A2GT	SKCM	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	0.1389
p.T75I	TCGA-G4-6628	COAD	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	0.2222
p.Q70H	TCGA-Q1-A5R2	CESC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	0.0833
p.G72R	TCGA-Q1-A73O	CESC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	0.1389
p.G72E	TCGA-Q1-A73O	CESC	TCGA	PFQTPFQS	DEG_SCF_FBW7_1	0.1389
p.R76W	DO7997	COAD	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.25
p.R69W	DO228068	EOPC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.0556
p.R69Q	DO233724	GACA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.0556
p.A87S	DO229035	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.3056
p.S83I	DO229041	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.7341
p.R85W	DO229051	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.8634
p.R85W	SNU-C5	large_intestine	COSMIC	PFQTPFQS	DEG_SCF_FBW7_1	0.8634
p.V95F	DO229006	LICA	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.0833
p.S72P	DO30420	OV	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.1389
p.S72F	DO49826	PRAD	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.1389
p.P91L	DO51299	SKCM	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.1944
p.P91S	DO51299	SKCM	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.1944
p.D88N	DO41020	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.2778
p.D88N	DO41379	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.2778
p.G71S	DO41686	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.1111
p.R75H	DO41871	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.2222
p.S89I	DO41361	UCEC	ICGC	PFQTPFQS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SCF_FBW7_1	79:86	PFQTPFQS	FBXW7	0.9375	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons