DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9325:9329

E3 ligase: SPOP

DEGRON score: 0.9855

ASA_SCORE: 78.62

COIL: 0.826

CONS_SCORE: 0

DSS_SCORE: 0.6383

HELIX: 0.031

FCONS_SCORE: 0

RIG_SCORE: 0.6848

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A9325D	TCGA-A4-7584	KIRP	TCGA	AISSS	DEG_SPOP_SBC_1	0.7793
p.A9325D	DO20869	KIRP	ICGC	AISSS	DEG_SPOP_SBC_1	0.7793
p.E9319D	TCGA-AP-A059	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	0.1667
p.E9319D	DO41361	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.E9319D	SIDM00721	Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.1667
p.E9319D	ACH-002171	Lung Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.1667
p.E9319D	NCI-H250	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	0.1667
p.S9329G	TCGA-BA-A4IF	HNSC	TCGA	AISSS	DEG_SPOP_SBC_1	0.6993
p.S9329G	DO49043	HNSC	ICGC	AISSS	DEG_SPOP_SBC_1	0.6993
p.P9334Q	TCGA-EE-A2GH	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.1944
p.P9334Q	DO37643	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.1944
p.T9318I	TCGA-EE-A3J7	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.1389
p.T9318I	DO48770	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.1389
p.R9330I	TCGA-EO-A22X	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	0.3056
p.R9330I	DO43907	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.P9334T	TCGA-GN-A262	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.1944
p.P9334T	DO37515	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.1944
p.T9331K	DO229045	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	0.2778
p.S9329N	DO220852	MELA	ICGC	AISSS	DEG_SPOP_SBC_1	0.7069
p.P9336S	DO220902	MELA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1389
p.S9332F	DO222887	MELA	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.R9330K	DO219878	SKCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.G9315V	SIDM00857	Melanoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.0556
p.G9315V	ACH-000572	Skin Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.0556
p.G9315V	G-361	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	0.0556
p.E9324D	SIDM00155	Head and Neck Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.3056
p.E9324D	ACH-002296	Head and Neck Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.3056
p.E9324D	PCI-38	upper_aerodigestive_tract	COSMIC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S9329R	SIDM00180	Kidney Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7427
p.S9329R	SIDM01645	Non-Cancerous	GDSC	AISSS	DEG_SPOP_SBC_1	0.7427
p.T9331A	ACH-001577	Leukemia	CCLE	AISSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	673:677	AISSS	SPOP	0.5288	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	515:519	AISSS	SPOP	0.8539	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	DEG_SPOP_SBC_1	423:427	AISSS	SPOP	0.9739	More...
Q5VWP3	Muscular LMNA-interacting protein	DEG_SPOP_SBC_1	165:169	AISSS	SPOP	0.9764	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3731:3735	AISSS	SPOP	0.789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	514:518	AISSS	SPOP	0.9574	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	385:389	AISSS	SPOP	0.9915	More...
Q7Z7G1	Cytokine-dependent hematopoietic cell linker	DEG_SPOP_SBC_1	241:245	AISSS	SPOP	0.99	More...
Q8IV76	Circadian clock protein PASD1	DEG_SPOP_SBC_1	663:667	AISSS	SPOP	0.9769	More...
Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	DEG_SPOP_SBC_1	494:498	AISSS	SPOP	0.9795	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	346:350	AISSS	SPOP	0.7859	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9325:9329	AISSS	SPOP	0.9855	More...
Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	DEG_SPOP_SBC_1	452:456	AISSS	SPOP	0.9867	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	828:832	AISSS	SPOP	0.9696	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	80:84	AISSS	SPOP	0.9244	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	121:125	AISSS	SPOP	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AISSS