DegronMD

Uniprot ID: Q16630

Source protein: Cleavage and polyadenylation specificity factor subunit 6

Source gene: CPSF6

Class: DEG_SPOP_SBC_1

Location: 423:427

E3 ligase: SPOP

DEGRON score: 0.9739

ASA_SCORE: 53.46

COIL: 0.4972

CONS_SCORE: 0.5896

DSS_SCORE: 0.3101

HELIX: 0.437

FCONS_SCORE: 1.0478

RIG_SCORE: 0.7317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M418I	TCGA-55-7994	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.1944
p.S430L	TCGA-AZ-4315	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.25
p.S430L	TCGA-F5-6814	READ	TCGA	AISSS	DEG_SPOP_SBC_1	0.25
p.A423E	TCGA-XK-AAIW	PRAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.7701
p.D431N	DO48457	BLCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.2222
p.P420L	DO220073	SARC	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.P420L	DO47631	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.S425L	ACH-000860	Lung Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.8778
p.S425L	ACH-000987	Skin Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.8778
p.S425L	NCI-H358	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	0.8778
p.S425L	Mewo	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	0.8778
p.A428D	ACH-000998	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.3056
p.A428D	CW-2	large_intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	0.3056
p.A423V	ACH-001459	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.5825
p.R420G	SK-OV-3	ovary	COSMIC	AISSS	DEG_SPOP_SBC_1	0.25
p.E419K	CAL-78	bone	COSMIC	AISSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	673:677	AISSS	SPOP	0.5288	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	515:519	AISSS	SPOP	0.8539	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	DEG_SPOP_SBC_1	423:427	AISSS	SPOP	0.9739	More...
Q5VWP3	Muscular LMNA-interacting protein	DEG_SPOP_SBC_1	165:169	AISSS	SPOP	0.9764	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3731:3735	AISSS	SPOP	0.789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	514:518	AISSS	SPOP	0.9574	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	385:389	AISSS	SPOP	0.9915	More...
Q7Z7G1	Cytokine-dependent hematopoietic cell linker	DEG_SPOP_SBC_1	241:245	AISSS	SPOP	0.99	More...
Q8IV76	Circadian clock protein PASD1	DEG_SPOP_SBC_1	663:667	AISSS	SPOP	0.9769	More...
Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	DEG_SPOP_SBC_1	494:498	AISSS	SPOP	0.9795	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	346:350	AISSS	SPOP	0.7859	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9325:9329	AISSS	SPOP	0.9855	More...
Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	DEG_SPOP_SBC_1	452:456	AISSS	SPOP	0.9867	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	828:832	AISSS	SPOP	0.9696	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	80:84	AISSS	SPOP	0.9244	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	121:125	AISSS	SPOP	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISSS

Degron related mutations and impact score

Drug responses associated with CPSF6 mutations

All proteins holding degron of AISSS