DegronMD - Q8IV76(PASD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S262Y	TCGA-19-5954	GBM	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.S262Y	DO11459	GBM	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.Y250D	TCGA-91-6828	LUAD	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1667
p.Y250D	DO26150	LUAD	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1667
p.E254D	TCGA-A5-A0GP	UCEC	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.E254D	DO41109	UCEC	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.E254K	TCGA-AP-A1DV	UCEC	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.E254K	DO43186	UCEC	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.D677Y	TCGA-AX-A06F	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.0556
p.D677Y	DO41752	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.0556
p.Q249R	TCGA-C8-A12V	BRCA	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.Q249R	DO4044	BRCA	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.P670S	TCGA-DA-A3F3	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.25
p.P670S	DO37607	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.25
p.P670L	TCGA-E6-A1LX	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.25
p.P670L	DO41020	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.25
p.P673S	TCGA-EB-A5SG	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1667
p.P673S	DO222868	MELA	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1667
p.P673S	DO48726	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1667
p.S262F	TCGA-EE-A3JD	SKCM	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.S262F	DO50299	SKCM	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.S666F	TCGA-FS-A4FD	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.7982
p.S666F	DO37699	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.7982
p.T270R	TCGA-HC-A6HX	PRAD	TCGA	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0833
p.T270R	DO46806	PRAD	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0833
p.P673L	TCGA-QC-A7B5	SARC	TCGA	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1667
p.P673L	DO220239	SARC	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1667
p.P670A	DO223534	CLLE	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.25
p.S661P	DO228551	GACA	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.2778
p.P654S	DO233652	GACA	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.0833
p.Y266H	DO233688	GACA	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1944
p.S264L	DO220906	MELA	ICGC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.25
p.T675P	DO46488	OV	ICGC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1111
p.T675P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1111
p.S668N	SIDM00683	Prostate Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.S668N	ACH-000977	lymph node	CCLE	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.N255I	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.N255I	ACH-000860	Lung Cancer	CCLE	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.N255I	NCI-H358	lung	COSMIC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.S667F	SIDM00538	Esophageal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.7982
p.S667F	ACH-001497	Esophageal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.7982
p.S667F	ESO51	oesophagus	COSMIC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.7982
p.L655M	SIDM00487	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1111
p.L655M	ACH-000963	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1111
p.L655M	CCK-81	large intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1111
p.D261Y	SIDM01588	Endometrial Carcinoma	GDSC	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7325
p.D261Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	VHMFVD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7325
p.I664V	ACH-000514	Lung Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.5965

Kaplan plot for PASD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PASD1

UniProt ID: Q8IV76

Entrez ID: 139135

Protein name: Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PASD1 in