DegronMD

Uniprot ID: Q8IV76

Source protein: Circadian clock protein PASD1

Source gene: PASD1

Class: DEG_SPOP_SBC_1

Location: 663:667

E3 ligase: SPOP

DEGRON score: 0.9769

ASA_SCORE: 79.18

COIL: 0.895

CONS_SCORE: 0.85

DSS_SCORE: 0.488

HELIX: 0.0584

FCONS_SCORE: 0.9049

RIG_SCORE: 0.6655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D677Y	TCGA-AX-A06F	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	0.0556
p.D677Y	DO41752	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	0.0556
p.P670S	TCGA-DA-A3F3	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.25
p.P670S	DO37607	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.P670L	TCGA-E6-A1LX	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	0.25
p.P670L	DO41020	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.P673S	TCGA-EB-A5SG	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.1667
p.P673S	DO222868	MELA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.P673S	DO48726	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.S666F	TCGA-FS-A4FD	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.7982
p.S666F	DO37699	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	0.7982
p.P673L	TCGA-QC-A7B5	SARC	TCGA	AISSS	DEG_SPOP_SBC_1	0.1667
p.P673L	DO220239	SARC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.P670A	DO223534	CLLE	ICGC	AISSS	DEG_SPOP_SBC_1	0.25
p.S661P	DO228551	GACA	ICGC	AISSS	DEG_SPOP_SBC_1	0.2778
p.P654S	DO233652	GACA	ICGC	AISSS	DEG_SPOP_SBC_1	0.0833
p.T675P	DO46488	OV	ICGC	AISSS	DEG_SPOP_SBC_1	0.1111
p.T675P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	0.1111
p.S668N	SIDM00683	Prostate Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S668N	ACH-000977	lymph_node	CCLE	AISSS	DEG_SPOP_SBC_1	0.3056
p.S667F	SIDM00538	Esophageal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7982
p.S667F	ACH-001497	Esophageal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.7982
p.S667F	ESO51	oesophagus	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7982
p.L655M	SIDM00487	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.1111
p.L655M	ACH-000963	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.1111
p.L655M	CCK-81	large_intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	0.1111
p.I664V	ACH-000514	Lung Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	673:677	AISSS	SPOP	0.5288	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	515:519	AISSS	SPOP	0.8539	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	DEG_SPOP_SBC_1	423:427	AISSS	SPOP	0.9739	More...
Q5VWP3	Muscular LMNA-interacting protein	DEG_SPOP_SBC_1	165:169	AISSS	SPOP	0.9764	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3731:3735	AISSS	SPOP	0.789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	514:518	AISSS	SPOP	0.9574	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	385:389	AISSS	SPOP	0.9915	More...
Q7Z7G1	Cytokine-dependent hematopoietic cell linker	DEG_SPOP_SBC_1	241:245	AISSS	SPOP	0.99	More...
Q8IV76	Circadian clock protein PASD1	DEG_SPOP_SBC_1	663:667	AISSS	SPOP	0.9769	More...
Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	DEG_SPOP_SBC_1	494:498	AISSS	SPOP	0.9795	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	346:350	AISSS	SPOP	0.7859	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9325:9329	AISSS	SPOP	0.9855	More...
Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	DEG_SPOP_SBC_1	452:456	AISSS	SPOP	0.9867	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	828:832	AISSS	SPOP	0.9696	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	80:84	AISSS	SPOP	0.9244	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	121:125	AISSS	SPOP	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISSS

Degron related mutations and impact score

Drug responses associated with PASD1 mutations

All proteins holding degron of AISSS