DegronMD - Q8N684(CPSF7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R35W	TCGA-37-A5EL	LUSC	TCGA	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2778
p.P40T	TCGA-50-5946	LUAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.1389
p.P40T	DO24556	LUAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.1389
p.D242V	TCGA-86-7714	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1944
p.I446V	TCGA-AA-3811	COAD	TCGA	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation rewiring degron network	0.3056
p.R244Q	TCGA-AA-A022	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.A344T	TCGA-AJ-A3BH	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2778
p.A344T	SIDM00086	Kidney Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2778
p.P325H	TCGA-AP-A051	UCEC	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation altering degron motif	0.7694
p.R244W	TCGA-B5-A3FC	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.P342T	TCGA-BQ-7055	KIRP	TCGA	AISSS	DEG_SPOP_SBC_1	346:350	Mutation blocking ubiquitination signal	0.6667
p.G326W	TCGA-CN-6010	HNSC	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation altering degron motif	0.7825
p.P336T	TCGA-CZ-5451	KIRC	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation rewiring degron network	0.1667
p.P336T	TCGA-CZ-5451	KIRC	TCGA	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0556
p.P325L	TCGA-EE-A2MD	SKCM	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation altering degron motif	0.7582
p.I33V	TCGA-HI-7170	PRAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.7076
p.I33V	DO36308	PRAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.7076
p.R257H	TCGA-KL-8346	KICH	TCGA	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.V258A	TCGA-L5-A8NM	ESCA	TCGA	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1389
p.S32P	TCGA-VQ-A8PD	STAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.7863
p.S32P	DO51768	STAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.7863
p.M354V	TCGA-WX-AA46	LIHC	TCGA	AISSS	DEG_SPOP_SBC_1	346:350	Mutation substituting flanking lysine	0.3333
p.E325K	DO51612	CESC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation altering degron motif	0.7022
p.T36I	DO233072	GACA	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.S357C	DO219056	HNSC	ICGC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1389
p.S330C	DO219056	HNSC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation altering degron motif	0.7541
p.A346E	DO229037	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7701
p.A24D	DO229008	LICA	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.I27V	DO230953	LUSC	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.3056
p.Q27H	DO32980	PACA	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.3056
p.A37V	DO229245	THCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.Q40R	DO42033	UCEC	ICGC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.1389
p.A342V	DO42312	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation blocking ubiquitination signal	0.6667
p.S325L	DO41020	UCEC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation altering degron motif	0.8778
p.P259S	DO41584	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.F337I	DO42472	UCEC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation rewiring degron network	0.1389
p.F337I	DO42472	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0833
p.N335S	SIDM02057	Colorectal Carcinoma	GDSC	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation rewiring degron network	0.1944
p.A358T	SIDM00845	Burkitt's Lymphoma	GDSC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1111
p.R431H	SIDM00850	Gastric Carcinoma	GDSC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation blocking phosphorylation signal	0.5556
p.R431H	AGS	stomach	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation blocking phosphorylation signal	0.5556
p.D315A	ACH-000382	Lung Cancer	CCLE	DSGPPPS	DEG_SCF_TRCP1_1	324:330	Mutation rewiring degron network	0.0833
p.R454W	ACH-000508	Lung Cancer	CCLE	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation rewiring degron network	0.0833
p.R454W	COR-L88	lung	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation rewiring degron network	0.0833
p.V34L	ACH-000838	Myeloma	CCLE	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.3056
p.V34L	AMO-1	haematopoietic and lymphoid tissue	COSMIC	IDLYDD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.3056
p.R438W	ACH-000989	Colon/Colorectal Cancer	CCLE	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation rewiring degron network	0.3056
p.R438W	SNU-175	large intestine	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation rewiring degron network	0.3056
p.D441E	ACH-000993	Endometrial/Uterine Cancer	CCLE	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation altering degron motif	0.6758
p.Y254H	LNCaP-Clone-FGC	prostate	COSMIC	PLSSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.R447W	SNU-175	large intestine	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	439:445	Mutation rewiring degron network	0.2778
p.I359V	SW48	large intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0833

Kaplan plot for CPSF7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPSF7

UniProt ID: Q8N684

Entrez ID: 79869

Protein name: Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPSF7 in