DegronMD

Uniprot ID: Q8N684

Source protein: Cleavage and polyadenylation specificity factor subunit 7

Source gene: CPSF7

Class: LIG_APCC_ABBA_1

Location: 28:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9467

ASA_SCORE: 50.5333

COIL: 0.5228

CONS_SCORE: 0.5386

DSS_SCORE: 0.6286

HELIX: 0.3492

FCONS_SCORE: 1.2554

RIG_SCORE: 0.8329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R35W	TCGA-37-A5EL	LUSC	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.2778
p.P40T	TCGA-50-5946	LUAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.1389
p.P40T	DO24556	LUAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.1389
p.I33V	TCGA-HI-7170	PRAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.7076
p.I33V	DO36308	PRAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.7076
p.S32P	TCGA-VQ-A8PD	STAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.7863
p.S32P	DO51768	STAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.7863
p.T36I	DO233072	GACA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.25
p.A24D	DO229008	LICA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.2222
p.I27V	DO230953	LUSC	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.3056
p.Q27H	DO32980	PACA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.3056
p.A37V	DO229245	THCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.2222
p.Q40R	DO42033	UCEC	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.1389
p.V34L	ACH-000838	Myeloma	CCLE	IDLYDD	LIG_APCC_ABBA_1	0.3056
p.V34L	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	IDLYDD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16630	Cleavage and polyadenylation specificity factor subunit 6	LIG_APCC_ABBA_1	30:35	IDLYDD	APC,CDC20,FZR1	0.8441	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	LIG_APCC_ABBA_1	28:33	IDLYDD	APC,CDC20,FZR1	0.9467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons