DegronMD

Uniprot ID: Q16630

Source protein: Cleavage and polyadenylation specificity factor subunit 6

Source gene: CPSF6

Class: LIG_APCC_ABBA_1

Location: 30:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8441

ASA_SCORE: 44.7

COIL: 0.4427

CONS_SCORE: 0.6319

DSS_SCORE: 0.5604

HELIX: 0.4133

FCONS_SCORE: 1.4921

RIG_SCORE: 0.8231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D35N	TCGA-A5-A0G2	UCEC	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.6932
p.D35N	DO48408	BLCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.6932
p.D35N	DO41235	UCEC	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.6932
p.Y33H	TCGA-AA-3715	COAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.6118
p.Y33H	DO8018	COAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.6118
p.G25C	TCGA-BF-A1PZ	SKCM	TCGA	IDLYDD	LIG_APCC_ABBA_1	0.1944
p.R26K	DO51893	BLCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.2222
p.T40S	DO230309	COCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.1944
p.N43D	DO233935	GACA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.1111
p.E21K	DO228963	LICA	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.0833
p.V45L	DO27987	OV	ICGC	IDLYDD	LIG_APCC_ABBA_1	0.0556
p.V41M	SNU-C2B	large_intestine	COSMIC	IDLYDD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16630	Cleavage and polyadenylation specificity factor subunit 6	LIG_APCC_ABBA_1	30:35	IDLYDD	APC,CDC20,FZR1	0.8441	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	LIG_APCC_ABBA_1	28:33	IDLYDD	APC,CDC20,FZR1	0.9467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons