DegronMD - Q16630(CPSF6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P383A	TCGA-17-Z000	LUAD	TCGA	PPPY	ITCH	387:390	Mutation rewiring degron network	0.2222
p.M418I	TCGA-55-7994	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.D35N	TCGA-A5-A0G2	UCEC	TCGA	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation altering degron motif	0.6932
p.D35N	DO48408	BLCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation altering degron motif	0.6932
p.D35N	DO41235	UCEC	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation altering degron motif	0.6932
p.Y33H	TCGA-AA-3715	COAD	TCGA	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation altering degron motif	0.6118
p.Y33H	DO8018	COAD	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation altering degron motif	0.6118
p.S430L	TCGA-AZ-4315	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.S430L	TCGA-F5-6814	READ	TCGA	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.G25C	TCGA-BF-A1PZ	SKCM	TCGA	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.1944
p.P383L	TCGA-D3-A1Q4	SKCM	TCGA	PPPY	ITCH	387:390	Mutation rewiring degron network	0.2222
p.P383L	TCGA-DX-AB2E	SARC	TCGA	PPPY	ITCH	387:390	Mutation rewiring degron network	0.2222
p.A423E	TCGA-XK-AAIW	PRAD	TCGA	AISSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7701
p.D431N	DO48457	BLCA	ICGC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222
p.R26K	DO51893	BLCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.2222
p.T40S	DO230309	COCA	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.1944
p.N43D	DO233935	GACA	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.1111
p.P378L	DO12058	GBM	ICGC	PPPY	ITCH	387:390	Mutation rewiring degron network	0.0833
p.P378L	DO26502	LUSC	ICGC	PPPY	ITCH	387:390	Mutation rewiring degron network	0.0833
p.P378S	DO228939	LICA	ICGC	PPPY	ITCH	387:390	Mutation rewiring degron network	0.0833
p.E21K	DO228963	LICA	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.0833
p.V45L	DO27987	OV	ICGC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.0556
p.P420L	DO220073	SARC	ICGC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.P420L	DO47631	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.H393Y	DO41241	UCEC	ICGC	PPPY	ITCH	387:390	Mutation rewiring degron network	0.25
p.S425L	ACH-000860	Lung Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.8778
p.S425L	ACH-000987	Skin Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.8778
p.S425L	NCI-H358	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.8778
p.S425L	Mewo	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.8778
p.A428D	ACH-000998	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.3056
p.A428D	CW-2	large intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.3056
p.A423V	ACH-001459	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.5825
p.V41M	SNU-C2B	large intestine	COSMIC	IDLYDD	LIG_APCC_ABBA_1	30:35	Mutation rewiring degron network	0.1667
p.R420G	SK-OV-3	ovary	COSMIC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.E419K	CAL-78	bone	COSMIC	AISSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222

Kaplan plot for CPSF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPSF6

UniProt ID: Q16630

Entrez ID: 11052

Protein name: Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPSF6 in