DegronMD

Uniprot ID: Q8N684

Source protein: Cleavage and polyadenylation specificity factor subunit 7

Source gene: CPSF7

Class: DEG_SCF_TRCP1_1

Location: 324:330

E3 ligase: BTRC

DEGRON score: 0.9905

ASA_SCORE: 76.6286

COIL: 0.9677

CONS_SCORE: 0.3908

DSS_SCORE: 0.6849

HELIX: 0.0126

FCONS_SCORE: 0.9779

RIG_SCORE: 0.5054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P325H	TCGA-AP-A051	UCEC	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	0.7694
p.G326W	TCGA-CN-6010	HNSC	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	0.7825
p.P336T	TCGA-CZ-5451	KIRC	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	0.1667
p.P325L	TCGA-EE-A2MD	SKCM	TCGA	DSGPPPS	DEG_SCF_TRCP1_1	0.7582
p.E325K	DO51612	CESC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	0.7022
p.S330C	DO219056	HNSC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	0.7541
p.S325L	DO41020	UCEC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	0.8778
p.F337I	DO42472	UCEC	ICGC	DSGPPPS	DEG_SCF_TRCP1_1	0.1389
p.N335S	SIDM02057	Colorectal Carcinoma	GDSC	DSGPPPS	DEG_SCF_TRCP1_1	0.1944
p.D315A	ACH-000382	Lung Cancer	CCLE	DSGPPPS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SCF_TRCP1_1	324:330	DSGPPPS	BTRC	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons