DegronMD

Uniprot ID: Q8N684

Source protein: Cleavage and polyadenylation specificity factor subunit 7

Source gene: CPSF7

Class: LIG_APCC_ABBAyCdc20_2

Location: 439:445

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9253

ASA_SCORE: 118.2571

COIL: 0.7906

CONS_SCORE: 0.4717

DSS_SCORE: 0.5858

HELIX: 0.208

FCONS_SCORE: 0.9679

RIG_SCORE: 0.5787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I446V	TCGA-AA-3811	COAD	TCGA	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R431H	SIDM00850	Gastric Carcinoma	GDSC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.5556
p.R431H	AGS	stomach	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.5556
p.R454W	ACH-000508	Lung Cancer	CCLE	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R454W	COR-L88	lung	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R438W	ACH-000989	Colon/Colorectal Cancer	CCLE	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R438W	SNU-175	large_intestine	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D441E	ACH-000993	Endometrial/Uterine Cancer	CCLE	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.6758
p.R447W	SNU-175	large_intestine	COSMIC	RDLLHNE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	LIG_APCC_ABBAyCdc20_2	439:445	RDLLHNE	APC,CDC20,FZR1	0.9253	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons