DegronMD

Uniprot ID: Q5VWP3

Source protein: Muscular LMNA-interacting protein

Source gene: MLIP

Class: DEG_SPOP_SBC_1

Location: 165:169

E3 ligase: SPOP

DEGRON score: 0.9764

ASA_SCORE: 71.84

COIL: 0.8196

CONS_SCORE: 0.8137

DSS_SCORE: 0.426

HELIX: 0.1178

FCONS_SCORE: 1.0864

RIG_SCORE: 0.7129

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R160L	TCGA-17-Z016	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.1944
p.D173N	TCGA-55-8205	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.2222
p.D173N	DO48884	LUAD	ICGC	AISSS	DEG_SPOP_SBC_1	0.2222
p.L170M	TCGA-78-7155	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.3056
p.I166F	TCGA-96-8170	LUSC	TCGA	AISSS	DEG_SPOP_SBC_1	0.6304
p.R176C	TCGA-A5-A0G2	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	0.1389
p.R160W	TCGA-CG-5726	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.1944
p.R160W	DO23108	LINC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1944
p.R160W	DO45041	LINC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1944
p.R160W	DO38483	STAD	ICGC	AISSS	DEG_SPOP_SBC_1	0.1944
p.R160W	ACH-000874	Leukemia	CCLE	AISSS	DEG_SPOP_SBC_1	0.1944
p.R160W	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	0.1944
p.R176H	TCGA-CM-5861	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	0.1389
p.S167L	TCGA-W3-A825	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.7667
p.S168F	TCGA-WE-AAA0	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	0.7982
p.P177S	DO48390	BLCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1111
p.D173G	DO48370	BLCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.2222
p.R170H	DO7918	COAD	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.R170H	DO51025	LAML	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S164T	DO229010	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S164T	DO229013	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S164T	DO229016	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S164T	DO229003	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.S164T	DO229005	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.3056
p.V159I	DO229010	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.V159I	DO229013	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.V159I	DO229016	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.V159I	DO229003	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.V159I	DO229005	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.V159I	DO229028	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	0.1667
p.G155C	DO233808	GACA	ICGC	AISSS	DEG_SPOP_SBC_1	0.0556
p.T166K	DO229229	THCA	ICGC	AISSS	DEG_SPOP_SBC_1	0.7306
p.V177L	DO42312	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	0.1111
p.G163R	SIDM00373	Endometrial Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM00496	Thyroid Gland Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM00489	Oral Cavity Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM01061	Oral Cavity Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SIDM00160	Biliary Tract Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	HTC-C3	thyroid	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	SNG-M	endometrium	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	PC-3_[JPC-3]	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	TE-9	oesophagus	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	HN	upper_aerodigestive_tract	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163R	Ca9-22	upper_aerodigestive_tract	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163V	SIDM00690	Head and Neck Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163V	SIDM00210	Ovarian Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163V	SIDM00879	Breast Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163V	SIDM00954	Breast Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163V	SIDM00785	Acute Myeloid Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G163V	SIDM01387	Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.7222
p.G160S	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.1944
p.G160S	SK-LU-1	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	0.1944
p.G166S	SIDM00999	Bladder Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	0.6993
p.G166S	639-V	urinary_tract	COSMIC	AISSS	DEG_SPOP_SBC_1	0.6993
p.R171W	SIDM01086	B-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	0.2778
p.R171W	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	0.2778
p.G155S	ACH-000973	Bladder Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	0.0556
p.G155S	639-V	urinary_tract	COSMIC	AISSS	DEG_SPOP_SBC_1	0.0556
p.P158L	MCC13	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	0.1389
p.D166N	COLO-783	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	0.6932
p.D166V	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	673:677	AISSS	SPOP	0.5288	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	515:519	AISSS	SPOP	0.8539	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	DEG_SPOP_SBC_1	423:427	AISSS	SPOP	0.9739	More...
Q5VWP3	Muscular LMNA-interacting protein	DEG_SPOP_SBC_1	165:169	AISSS	SPOP	0.9764	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3731:3735	AISSS	SPOP	0.789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	514:518	AISSS	SPOP	0.9574	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	385:389	AISSS	SPOP	0.9915	More...
Q7Z7G1	Cytokine-dependent hematopoietic cell linker	DEG_SPOP_SBC_1	241:245	AISSS	SPOP	0.99	More...
Q8IV76	Circadian clock protein PASD1	DEG_SPOP_SBC_1	663:667	AISSS	SPOP	0.9769	More...
Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	DEG_SPOP_SBC_1	494:498	AISSS	SPOP	0.9795	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	346:350	AISSS	SPOP	0.7859	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9325:9329	AISSS	SPOP	0.9855	More...
Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	DEG_SPOP_SBC_1	452:456	AISSS	SPOP	0.9867	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	828:832	AISSS	SPOP	0.9696	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	80:84	AISSS	SPOP	0.9244	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	121:125	AISSS	SPOP	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISSS

Degron related mutations and impact score

Drug responses associated with MLIP mutations

All proteins holding degron of AISSS