DegronMD - P55199(ELL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L425I	TCGA-2W-A8YY	CESC	TCGA	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.6063
p.S519L	TCGA-AA-A022	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.8778
p.S519L	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	AISSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.8778
p.S519L	ACH-000226	Lymphoma	CCLE	AISSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.8778
p.S519L	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.8778
p.A515V	TCGA-CG-5733	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.5825
p.P500S	TCGA-D3-A2J7	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	499:503	Mutation altering degron motif	0.5641
p.L429P	TCGA-EY-A1H0	UCEC	TCGA	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.6471
p.T503M	TCGA-FI-A2D0	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	499:503	Mutation altering degron motif	0.7423
p.T506M	TCGA-HU-A4G9	STAD	TCGA	VPTST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.25
p.T506M	TCGA-HU-A4G9	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.0833
p.T437I	DO234344	ESAD	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation blocking phosphorylation signal	0.6111
p.I413T	DO233885	GACA	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.0556
p.T418I	DO222595	MELA	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.1944
p.R415Q	DO37591	SKCM	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.1111
p.R425W	DO37819	SKCM	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.8634
p.R425W	DO41380	UCEC	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.8634
p.L427F	DO37719	SKCM	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.6981
p.R415W	DO47817	STAD	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.1111
p.E415Q	SIDM00234	Other Solid Cancers	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.1111
p.A514T	SIDM00064	Hepatocellular Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514T	ACH-000393	Liver Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514T	ACH-001089	Liver Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514T	HLE	liver	COSMIC	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.R424C	SIDM00696	Non-Cancerous	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.8301
p.G426S	SIDM00402	Bladder Carcinoma	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.5882
p.A514V	SIDM01609	Endometrial Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514V	ACH-000972	Endometrial/Uterine Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A434V	SIDM00500	Colorectal Carcinoma	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.25
p.S497F	ACH-002396	Bone Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.2778
p.S497F	Sarc9371	bone	COSMIC	VPTST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.2778
p.Q426R	NCI-H2342	lung	COSMIC	VRLGLPLLT	DEG_APCC_DBOX_1	423:431	Mutation altering degron motif	0.7329
p.S498R	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.3056

Kaplan plot for ELL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ELL

UniProt ID: P55199

Entrez ID: 8178

Protein name: RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ELL in