DegronMD

Uniprot ID: P55199

Source protein: RNA polymerase II elongation factor ELL

Source gene: ELL

Class: DEG_APCC_DBOX_1

Location: 423:431

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9675

ASA_SCORE: 88.1

COIL: 0.8091

CONS_SCORE: 0.3493

DSS_SCORE: 0.5536

HELIX: 0.1128

FCONS_SCORE: 0.9941

RIG_SCORE: 0.7448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L425I	TCGA-2W-A8YY	CESC	TCGA	VRLGLPLLT	DEG_APCC_DBOX_1	0.6063
p.L429P	TCGA-EY-A1H0	UCEC	TCGA	VRLGLPLLT	DEG_APCC_DBOX_1	0.6471
p.T437I	DO234344	ESAD	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.6111
p.I413T	DO233885	GACA	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.0556
p.T418I	DO222595	MELA	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.1944
p.R415Q	DO37591	SKCM	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.1111
p.R425W	DO37819	SKCM	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.8634
p.R425W	DO41380	UCEC	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.8634
p.L427F	DO37719	SKCM	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.6981
p.R415W	DO47817	STAD	ICGC	VRLGLPLLT	DEG_APCC_DBOX_1	0.1111
p.E415Q	SIDM00234	Other Solid Cancers	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	0.1111
p.R424C	SIDM00696	Non-Cancerous	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	0.8301
p.G426S	SIDM00402	Bladder Carcinoma	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	0.5882
p.A434V	SIDM00500	Colorectal Carcinoma	GDSC	VRLGLPLLT	DEG_APCC_DBOX_1	0.25
p.Q426R	NCI-H2342	lung	COSMIC	VRLGLPLLT	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55199	RNA polymerase II elongation factor ELL	DEG_APCC_DBOX_1	423:431	VRLGLPLLT	APC,CDC20,FZR1	0.9675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons