DegronMD

Uniprot ID: P55199

Source protein: RNA polymerase II elongation factor ELL

Source gene: ELL

Class: DEG_SPOP_SBC_1

Location: 499:503

E3 ligase: SPOP

DEGRON score: 0.8985

ASA_SCORE: 73.32

COIL: 0.8898

CONS_SCORE: 0.4028

DSS_SCORE: 0.4317

HELIX: 0.039

FCONS_SCORE: 0.9057

RIG_SCORE: 0.6615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P500S	TCGA-D3-A2J7	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	0.5641
p.T503M	TCGA-FI-A2D0	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.7423
p.T506M	TCGA-HU-A4G9	STAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.25
p.S497F	ACH-002396	Bone Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	0.2778
p.S497F	Sarc9371	bone	COSMIC	VPTST	DEG_SPOP_SBC_1	0.2778
p.S498R	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29401	Transketolase	DEG_SPOP_SBC_1	440:444	VPTST	SPOP	0.7263	More...
P51843	Nuclear receptor subfamily 0 group B member 1	DEG_SPOP_SBC_1	216:220	VPTST	SPOP	0.6965	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	499:503	VPTST	SPOP	0.8985	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	DEG_SPOP_SBC_1	1750:1754	VPTST	SPOP	0.9683	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	519:523	VPTST	SPOP	0.6443	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2415:2419	VPTST	SPOP	0.8829	More...
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SPOP_SBC_1	193:197	VPTST	SPOP	0.9832	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1433:1437	VPTST	SPOP	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons