DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SPOP_SBC_1

Location: 1433:1437

E3 ligase: SPOP

DEGRON score: 0.9542

ASA_SCORE: 84

COIL: 0.9268

CONS_SCORE: 0.3203

DSS_SCORE: 0.328

HELIX: 0.036

FCONS_SCORE: 0.9257

RIG_SCORE: 0.7622

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1444N	TCGA-85-8049	LUSC	TCGA	VPTST	DEG_SPOP_SBC_1	0.1389
p.E1439D	TCGA-AP-A0LM	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.2778
p.T1445A	TCGA-BR-8081	STAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.1111
p.G1436V	DO229026	LICA	ICGC	VPTST	DEG_SPOP_SBC_1	0.7532
p.Q1432P	DO36556	READ	ICGC	VPTST	DEG_SPOP_SBC_1	0.3056
p.I1424M	SIDM00373	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00234	Other Solid Cancers	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00569	Osteosarcoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00040	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00260	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00351	Oral Cavity Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00580	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00560	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00248	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM00173	Head and Neck Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SIDM01662	Plasma Cell Myeloma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	TMK-1	stomach	COSMIC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	RERF-LC-KJ	lung	COSMIC	VPTST	DEG_SPOP_SBC_1	0.0833
p.I1424M	SNG-M	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	0.0833
p.D1431A	SIDM00845	Burkitt's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778
p.D1431A	SIDM01519	Head and Neck Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778
p.P1429L	ACH-000958	Colon/Colorectal Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	0.2222
p.P1429L	SW48	large_intestine	COSMIC	VPTST	DEG_SPOP_SBC_1	0.2222
p.I1432M	TMK-1	stomach	COSMIC	VPTST	DEG_SPOP_SBC_1	0.3056
p.I1432M	RERF-LC-KJ	lung	COSMIC	VPTST	DEG_SPOP_SBC_1	0.3056
p.I1432M	SNG-M	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	0.3056
p.G1425V	RL	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1111
p.L1430V	RKO	large_intestine	COSMIC	VPTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29401	Transketolase	DEG_SPOP_SBC_1	440:444	VPTST	SPOP	0.7263	More...
P51843	Nuclear receptor subfamily 0 group B member 1	DEG_SPOP_SBC_1	216:220	VPTST	SPOP	0.6965	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	499:503	VPTST	SPOP	0.8985	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	DEG_SPOP_SBC_1	1750:1754	VPTST	SPOP	0.9683	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	519:523	VPTST	SPOP	0.6443	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2415:2419	VPTST	SPOP	0.8829	More...
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SPOP_SBC_1	193:197	VPTST	SPOP	0.9832	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1433:1437	VPTST	SPOP	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTST

Degron related mutations and impact score

Drug responses associated with WNK1 mutations

All proteins holding degron of VPTST