DegronMD

Uniprot ID: Q01668

Source protein: Voltage-dependent L-type calcium channel subunit alpha-1D

Source gene: CACNA1D

Class: DEG_SPOP_SBC_1

Location: 1750:1754

E3 ligase: SPOP

DEGRON score: 0.9683

ASA_SCORE: 85.46

COIL: 0.9198

CONS_SCORE: 0.1602

DSS_SCORE: 0.6498

HELIX: 0.039

FCONS_SCORE: 0.7912

RIG_SCORE: 0.6857

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1744S	TCGA-06-1805	GBM	TCGA	VPTST	DEG_SPOP_SBC_1	0.1667
p.P1751S	TCGA-AP-A051	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.5641
p.S1755L	TCGA-AP-A1DV	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.S1755L	TCGA-BR-8286	STAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.S1755L	TCGA-DA-A1IC	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.S1755L	TCGA-DA-A95X	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.S1755L	TCGA-E6-A1LX	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.S1755L	SIDM01307	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.3056
p.P1750L	TCGA-EY-A1GK	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.7582
p.P1750L	DO42985	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.7582
p.P1750H	DO50511	BOCA	ICGC	VPTST	DEG_SPOP_SBC_1	0.7694
p.P1750H	DO227549	COCA	ICGC	VPTST	DEG_SPOP_SBC_1	0.7694
p.R1756W	DO7776	COAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.2778
p.R1756W	DO41235	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.2778
p.N1740T	DO28681	OV	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.A1746V	DO232224	PBCA	ICGC	VPTST	DEG_SPOP_SBC_1	0.2222
p.R1756Q	DO43899	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.2778
p.N1764S	SIDM00373	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0556
p.N1764K	SIDM01088	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.0556
p.N1764K	RL95-2	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	0.0556
p.R1756P	ACH-000786	Lymphoma	CCLE	VPTST	DEG_SPOP_SBC_1	0.2778
p.R1756P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.2778
p.N1744S	ACH-000974	Endometrial/Uterine Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	0.1667
p.V1756G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.2778
p.V1756G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.2778
p.V1756G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.2778
p.V1750A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.5825
p.V1750A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.5825
p.V1750A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.5825
p.N1753K	RL95-2	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	0.6918
p.V1745G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1944
p.V1745G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1944
p.V1745G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1944
p.N1744K	RL95-2	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1667
p.V1759A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1944
p.V1759A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1944
p.V1759A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29401	Transketolase	DEG_SPOP_SBC_1	440:444	VPTST	SPOP	0.7263	More...
P51843	Nuclear receptor subfamily 0 group B member 1	DEG_SPOP_SBC_1	216:220	VPTST	SPOP	0.6965	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	499:503	VPTST	SPOP	0.8985	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	DEG_SPOP_SBC_1	1750:1754	VPTST	SPOP	0.9683	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	519:523	VPTST	SPOP	0.6443	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2415:2419	VPTST	SPOP	0.8829	More...
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SPOP_SBC_1	193:197	VPTST	SPOP	0.9832	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1433:1437	VPTST	SPOP	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTST

Degron related mutations and impact score

Drug responses associated with CACNA1D mutations

All proteins holding degron of VPTST