DegronMD - Q9H0M0(WWP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y206H	TCGA-21-1080	LUSC	TCGA	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.Y206H	DO26502	LUSC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.Y206N	TCGA-69-7979	LUAD	TCGA	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.Y206N	DO23874	LUAD	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.D253Y	TCGA-69-8253	LUAD	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2222
p.A268V	TCGA-85-6560	LUSC	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2222
p.G188V	TCGA-85-8354	LUSC	TCGA	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.G188V	DO45467	LUSC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.V193A	TCGA-B5-A11E	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.5825
p.V193A	DO41644	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.5825
p.C204Y	TCGA-D1-A101	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.C204Y	DO43955	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.N272K	TCGA-EJ-8474	PRAD	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.1111
p.N191T	TCGA-EO-A22R	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.N191T	DO42713	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.S264C	TCGA-WQ-AB4B	LIHC	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.7541
p.P255L	DO48576	BLCA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2778
p.R266S	DO477	BLCA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2778
p.R264H	DO223732	CESC	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.8244
p.R264H	DO229050	LICA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.8244
p.R266I	DO222798	COCA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2778
p.P255T	DO14282	HNSC	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2778
p.V193L	DO228976	LICA	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.6765
p.E195D	DO23248	LINC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.6758
p.E248D	DO218940	LUAD	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.0833
p.H272R	DO45410	LUAD	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.1111
p.Y268H	DO45314	LUAD	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.2222
p.R265K	DO37442	SKCM	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.3056
p.A197T	DO47769	STAD	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.7139
p.V261A	DO43274	UCEC	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.6936
p.D203G	DO42504	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.P202T	DO42673	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.V257I	SIDM00683	Prostate Carcinoma	GDSC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.5965
p.V257I	ACH-000977	lymph node	CCLE	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.5965
p.V257I	LNCaP-Clone-FGC	prostate	COSMIC	VTGTPVVS	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.5965

Kaplan plot for WWP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WWP1

UniProt ID: Q9H0M0

Entrez ID: 11059

Protein name: NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WWP1 in