DegronMD

Uniprot ID: Q9H0M0

Source protein: NEDD4-like E3 ubiquitin-protein ligase WWP1

Source gene: WWP1

Class: DEG_SPOP_SBC_1

Location: 193:197

E3 ligase: SPOP

DEGRON score: 0.9832

ASA_SCORE: 76.82

COIL: 0.8984

CONS_SCORE: 0.4298

DSS_SCORE: 0.408

HELIX: 0.0462

FCONS_SCORE: 0.992

RIG_SCORE: 0.776

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A197T	DO47769	STAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.7139
p.V193L	DO228976	LICA	ICGC	VPTST	DEG_SPOP_SBC_1	0.6765
p.E195D	DO23248	LINC	ICGC	VPTST	DEG_SPOP_SBC_1	0.6758
p.V193A	TCGA-B5-A11E	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.5825
p.V193A	DO41644	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.5825
p.N191T	TCGA-EO-A22R	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.2778
p.N191T	DO42713	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.2778
p.G188V	TCGA-85-8354	LUSC	TCGA	VPTST	DEG_SPOP_SBC_1	0.1944
p.G188V	DO45467	LUSC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1944
p.P202T	DO42673	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1944
p.D203G	DO42504	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1667
p.C204Y	TCGA-D1-A101	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.1389
p.C204Y	DO43955	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1389
p.Y206H	TCGA-21-1080	LUSC	TCGA	VPTST	DEG_SPOP_SBC_1	0.0833
p.Y206H	DO26502	LUSC	ICGC	VPTST	DEG_SPOP_SBC_1	0.0833
p.Y206N	TCGA-69-7979	LUAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.0833
p.Y206N	DO23874	LUAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2415:2419	VPTST	SPOP	0.8829	More...
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SPOP_SBC_1	193:197	VPTST	SPOP	0.9832	More...
P51843	Nuclear receptor subfamily 0 group B member 1	DEG_SPOP_SBC_1	216:220	VPTST	SPOP	0.6965	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	519:523	VPTST	SPOP	0.6443	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	499:503	VPTST	SPOP	0.8985	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1433:1437	VPTST	SPOP	0.9542	More...
P29401	Transketolase	DEG_SPOP_SBC_1	440:444	VPTST	SPOP	0.7263	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	DEG_SPOP_SBC_1	1750:1754	VPTST	SPOP	0.9683	More...

Showing 1 to 8 of 8 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons