DegronMD

Uniprot ID: P51843

Source protein: Nuclear receptor subfamily 0 group B member 1

Source gene: NR0B1

Class: DEG_SPOP_SBC_1

Location: 216:220

E3 ligase: SPOP

DEGRON score: 0.6965

ASA_SCORE: 69.28

COIL: 0.8328

CONS_SCORE: 0.3272

DSS_SCORE: 0.422

HELIX: 0.057

FCONS_SCORE: 0.9992

RIG_SCORE: 0.7827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H206Q	TCGA-AC-A4ZE	BRCA	TCGA	VPTST	DEG_SPOP_SBC_1	0.0556
p.H206Q	DO223930	BRCA	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.P207L	TCGA-CM-6675	COAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.0833
p.P207L	DO10349	COAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.0833
p.T218M	TCGA-D5-6533	COAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.7423
p.T218M	DO8280	COAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.7423
p.T218M	DO42673	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.7423
p.T218M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	0.7423
p.R230Q	TCGA-D5-6541	COAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.0556
p.R230Q	DO10389	COAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.A226T	TCGA-EO-A22R	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.1667
p.A226T	DO42713	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1667
p.R230W	TCGA-FU-A3TQ	CESC	TCGA	VPTST	DEG_SPOP_SBC_1	0.0556
p.R230W	DO44295	CESC	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.R230W	DO47911	STAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.Q208R	DO228096	EOPC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1111
p.Q208R	DO229232	THCA	ICGC	VPTST	DEG_SPOP_SBC_1	0.1111
p.R230P	DO25444	LUAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.A225V	SIDM00216	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.1944
p.A225V	ACH-000989	Colon/Colorectal Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29401	Transketolase	DEG_SPOP_SBC_1	440:444	VPTST	SPOP	0.7263	More...
P51843	Nuclear receptor subfamily 0 group B member 1	DEG_SPOP_SBC_1	216:220	VPTST	SPOP	0.6965	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	499:503	VPTST	SPOP	0.8985	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	DEG_SPOP_SBC_1	1750:1754	VPTST	SPOP	0.9683	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	519:523	VPTST	SPOP	0.6443	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2415:2419	VPTST	SPOP	0.8829	More...
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SPOP_SBC_1	193:197	VPTST	SPOP	0.9832	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1433:1437	VPTST	SPOP	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons