DegronMD - Q6ZS17(RIPOR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A633T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1111
p.P505T	SIDM01039	Other Solid Cancers	GDSC	ATSST	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.25
p.P505T	JAR	placenta	COSMIC	ATSST	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.25
p.T603S	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation altering degron motif	0.6005
p.T603S	DB	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation altering degron motif	0.6005
p.G557S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AITTT	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2778
p.G557S	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	AITTT	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2778
p.P500H	SIDM00438	B-Lymphoblastic Leukemia	GDSC	ATSST	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.P500H	MN-60	haematopoietic and lymphoid tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.I612T	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.0833
p.I612T	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.0833
p.P503A	SIDM00168	Head and Neck Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1944
p.A730T	HCT-116	large intestine	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	726:732	Mutation altering degron motif	0.7139
p.L570I	HCT-116	large intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1389
p.S639P	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2778
p.L566I	HCT-116	large intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.25
p.T613A	SNU-1040	large intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.0556
p.G551S	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	AITTT	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1111
p.T597S	DB	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.2778
p.S733N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	726:732	Mutation rewiring degron network	0.3056
p.T603A	SNU-1040	large intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation altering degron motif	0.7139
p.I606T	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.25
p.S737N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	726:732	Mutation rewiring degron network	0.1944
p.S633P	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1111
p.I596T	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.25
p.T599A	SNU-1040	large intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation altering degron motif	0.7139
p.P499T	JAR	placenta	COSMIC	ATSST	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.S739N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	726:732	Mutation substituting flanking lysine	0.25
p.A734T	HCT-116	large intestine	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	726:732	Mutation rewiring degron network	0.2778
p.I592T	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1389

Kaplan plot for RIPOR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIPOR1

UniProt ID: Q6ZS17

Entrez ID: 79567

Protein name: Rho family-interacting cell polarization regulator 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIPOR1 in