DegronMD

Uniprot ID: Q6ZS17

Source protein: Rho family-interacting cell polarization regulator 1

Source gene: RIPOR1

Class: DEG_SPOP_SBC_1

Location: 559:563

E3 ligase: SPOP

DEGRON score: 0.9741

ASA_SCORE: 85.04

COIL: 0.9356

CONS_SCORE: 0.2299

DSS_SCORE: 0.6011

HELIX: 0.0192

FCONS_SCORE: 0.892

RIG_SCORE: 0.6954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G557S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AITTT	DEG_SPOP_SBC_1	0.2778
p.G557S	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	AITTT	DEG_SPOP_SBC_1	0.2778
p.L570I	HCT-116	large_intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	0.1389
p.L566I	HCT-116	large_intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	0.25
p.G551S	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	AITTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26010	Integrin beta-7	DEG_SPOP_SBC_1	781:785	AITTT	SPOP	0.9546	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1471:1475	AITTT	SPOP	0.8409	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	559:563	AITTT	SPOP	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons