DegronMD - P51610(HCFC1)

FUNCTION: Transcriptional coregulator (By similarity). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T771I	TCGA-23-1121	OV	TCGA	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation blocking phosphorylation signal	0.6667
p.T771I	DO28731	OV	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation blocking phosphorylation signal	0.6667
p.V1476M	TCGA-2W-A8YY	CESC	TCGA	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.3056
p.V1476M	DO223732	CESC	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.3056
p.R479S	TCGA-55-7576	LUAD	TCGA	SSISVPTA	DEG_COP1_1	470:477	Mutation rewiring degron network	0.2778
p.R479S	DO24431	LUAD	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation rewiring degron network	0.2778
p.M951I	TCGA-55-8089	LUAD	TCGA	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.3056
p.M951I	DO23690	LUAD	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.3056
p.V756F	TCGA-61-2016	OV	TCGA	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1389
p.V756F	TCGA-QH-A6CU	LGG	TCGA	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1389
p.V756F	DO44532	LGG	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1389
p.V756F	DO28461	OV	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1389
p.R1482L	TCGA-66-2734	LUSC	TCGA	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482L	TCGA-D3-A2J6	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482L	DO26430	LUSC	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482L	DO37901	SKCM	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.G896R	TCGA-86-A4JF	LUAD	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.G896R	TCGA-IB-7651	PAAD	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.G896R	DO45317	LUAD	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.G896R	DO46657	PAAD	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.A1593P	TCGA-98-A538	LUSC	TCGA	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.2222
p.A1593P	DO219177	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.2222
p.R1482W	TCGA-A5-A2K3	UCEC	TCGA	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482W	DO1131	BRCA	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482W	DO43899	UCEC	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.A941V	TCGA-A6-5665	COAD	TCGA	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.25
p.A941V	DO9756	COAD	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.25
p.A776V	TCGA-AA-3947	COAD	TCGA	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.A776V	DO8192	COAD	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.A897V	TCGA-AJ-A3BG	UCEC	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0833
p.A897V	DO42633	UCEC	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0833
p.E1610D	TCGA-AP-A0LM	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.0833
p.E1610D	DO43306	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.0833
p.T405K	TCGA-AR-A256	BRCA	TCGA	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1944
p.T405K	DO4155	BRCA	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1944
p.A1471V	TCGA-AX-A2HD	UCEC	TCGA	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.5825
p.A1471V	DO42608	UCEC	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.5825
p.G914D	TCGA-BG-A222	UCEC	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.2778
p.G914D	DO42977	UCEC	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.2778
p.T476A	TCGA-BG-A222	UCEC	TCGA	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.7139
p.T476A	DO42977	UCEC	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.7139
p.T908M	TCGA-CD-A4MG	STAD	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7423
p.T908M	TCGA-CK-5916	COAD	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7423
p.T908M	TCGA-PG-A6IB	UCEC	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7423
p.T908M	DO8786	COAD	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7423
p.T908M	DO48009	STAD	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7423
p.T908M	DO52419	UCEC	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7423
p.P1831Q	TCGA-CF-A8HX	BLCA	TCGA	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1389
p.A1597V	TCGA-CQ-6219	HNSC	TCGA	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation altering degron motif	0.5825
p.L1856P	TCGA-CV-A6K1	HNSC	TCGA	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1111
p.L1856P	DO52078	HNSC	ICGC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1111
p.Q956K	TCGA-D3-A2J8	SKCM	TCGA	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1667
p.Q956K	DO37778	SKCM	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1667
p.S905F	TCGA-D3-A8GI	SKCM	TCGA	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.3056
p.S905F	DO50284	SKCM	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.3056
p.S473F	TCGA-D9-A6EC	SKCM	TCGA	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.6871
p.S473F	DO50291	SKCM	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.6871
p.R1169C	TCGA-DF-A2KU	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation rewiring degron network	0.2222
p.R1169C	DO223286	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation rewiring degron network	0.2222
p.A477T	TCGA-DF-A2KV	UCEC	TCGA	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.7139
p.A477T	DO219771	UCEC	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.7139
p.P416R	TCGA-DU-A5TU	LGG	TCGA	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation altering degron motif	0.6401
p.P416R	DO44579	LGG	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation altering degron motif	0.6401
p.S598L	TCGA-EB-A3XD	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.5
p.S598L	DO37871	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.5
p.P416T	TCGA-EB-A553	SKCM	TCGA	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation altering degron motif	0.5919
p.P416T	DO47329	SKCM	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation altering degron motif	0.5919
p.E1594K	TCGA-EC-A24G	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.25
p.E1594K	DO40996	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.25
p.S1478F	TCGA-EE-A2GL	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.25
p.S1478F	DO37434	SKCM	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.25
p.G764S	TCGA-EY-A2OM	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.5882
p.G764S	DO43025	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.5882
p.G943W	TCGA-FS-A1ZG	SKCM	TCGA	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.3056
p.G943W	DO37523	SKCM	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.3056
p.E1809Q	TCGA-G7-A8LE	KIRP	TCGA	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation altering degron motif	0.6744
p.D1833G	TCGA-KK-A7AV	PRAD	TCGA	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1944
p.D1833G	DO219301	PRAD	ICGC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1944
p.A591V	DO224577	BRCA	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.2222
p.A591V	DO224577	BRCA	ICGC	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.25
p.T1481M	DO228483	BRCA	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM00434	Plasma Cell Myeloma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM00565	Oral Cavity Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM00580	Acute Myeloid Leukemia	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM00988	Kidney Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM00170	Head and Neck Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM01446	Glioblastoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	SIDM01442	Glioma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	BFTC-909	kidney	COSMIC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	OSC-20	upper aerodigestive tract	COSMIC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.T1481M	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.A1173T	DO222946	BTCA	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation altering degron motif	0.7139
p.S1164P	DO230334	COCA	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation blocking phosphorylation signal	0.5278
p.S1164P	DO229010	COCA	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation blocking phosphorylation signal	0.5278
p.S1164P	DO229016	COCA	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation blocking phosphorylation signal	0.5278
p.S1164P	DO229003	COCA	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation blocking phosphorylation signal	0.5278
p.S1164P	DO230998	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation blocking phosphorylation signal	0.5278
p.L1800M	DO227996	COCA	ICGC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.1389
p.V756I	DO52450	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1389
p.M580V	DO233267	GACA	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	580:587	Mutation altering degron motif	0.6097
p.T937M	DO233272	GACA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1389
p.A940V	DO233867	GACA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.2222
p.E1854Q	DO51555	KIRP	ICGC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1667
p.M774I	DO228912	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1389
p.Q1589K	DO228976	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.1111
p.S754R	DO229022	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.S755R	DO229022	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation blocking phosphorylation signal	0.5556
p.T948N	DO229027	LICA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.5944
p.A429D	DO229031	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.0833
p.A429D	DO229008	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.0833
p.A478D	DO229037	LICA	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation rewiring degron network	0.3056
p.D1839E	DO229041	LICA	ICGC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation altering degron motif	0.5647
p.S411F	DO229058	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation altering degron motif	0.7982
p.A406D	DO229006	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.2222
p.A897E	DO229008	LICA	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0833
p.E1610K	DO50970	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.0833
p.E1610K	DO230934	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.0833
p.P571Q	DO229303	LMS	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.0833
p.L944P	DO229098	LMS	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.6471
p.Q1603K	DO45390	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.2778
p.T460A	DO231051	LUSC	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation rewiring degron network	0.0556
p.L1587R	DO220866	MELA	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.0556
p.G1843D	DO220913	MELA	ICGC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation altering degron motif	0.6087
p.P1801L	DO222532	MELA	ICGC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.1667
p.L589F	DO222868	MELA	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.2778
p.L589F	DO222868	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.3056
p.L944F	DO49203	PACA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.6981
p.N1465K	DO229459	SKCA	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1667
p.P763L	DO218906	SKCA	ICGC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.7582
p.D1592N	DO37750	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.1944
p.G896W	DO229259	THCA	ICGC	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.I1466T	DO229213	THCA	ICGC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1944
p.P421S	DO229213	THCA	ICGC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.3056
p.P947L	DO229229	THCA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.7582
p.P475S	DO229221	THCA	ICGC	SSISVPTA	DEG_COP1_1	470:477	Mutation altering degron motif	0.6752
p.Q1167K	DO229234	THCA	ICGC	ATSTT	DEG_SPOP_SBC_1	1173:1177	Mutation rewiring degron network	0.1667
p.A1590T	DO43891	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.1389
p.T1605M	DO42673	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.2222
p.P590T	SIDM01943	Colorectal Carcinoma	GDSC	MAVTPGTT	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.25
p.P590T	SIDM01943	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.2778
p.V954L	SIDM02021	Esophageal Carcinoma	GDSC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.2222
p.T588A	SIDM00305	Ovarian Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7139
p.T588A	JHOS-2	ovary	COSMIC	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7139
p.P1798L	SIDM00683	Prostate Carcinoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.0833
p.P1798L	ACH-000977	lymph node	CCLE	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.0833
p.P1798L	LNCaP-Clone-FGC	prostate	COSMIC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.0833
p.T1473M	SIDM00781	Colorectal Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7423
p.T1473M	SIDM00780	Colorectal Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7423
p.T1473M	ACH-000967	Colon/Colorectal Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7423
p.T1473M	ACH-001199	Colon/Colorectal Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7423
p.T1473M	SNU-C2B	large intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7423
p.T767A	SIDM00654	Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.7139
p.T767A	ACH-000866	Lung Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.7139
p.T767A	NCI-H1048	lung	COSMIC	PGTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.7139
p.M1806I	SIDM00719	Small Cell Lung Carcinoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.3056
p.M1806I	SIDM00327	Hodgkin's Lymphoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.3056
p.A1804T	SIDM01148	Plasma Cell Myeloma	GDSC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.25
p.A1804T	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation rewiring degron network	0.25
p.F1829L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.0833
p.F1829L	ACH-000980	Lung Cancer	CCLE	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.0833
p.F1829L	NCI-H1155	lung	COSMIC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.0833
p.R1482Q	SIDM00217	Colorectal Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482Q	ACH-000999	Colon/Colorectal Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1482Q	SNU-1040	large intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.P428S	SIDM00217	Colorectal Carcinoma	GDSC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.P428S	ACH-000999	Colon/Colorectal Cancer	CCLE	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.P428S	SNU-1040	large intestine	COSMIC	TSPTPNPVPSV	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.G1606W	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation rewiring degron network	0.1944
p.P1837T	SIDM00780	Colorectal Carcinoma	GDSC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.3056
p.G1597E	ACH-000001	Ovarian Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation altering degron motif	0.7199
p.G1597E	OVCAR-3	ovary	COSMIC	AGTTT	DEG_SPOP_SBC_1	1597:1601	Mutation altering degron motif	0.7199
p.A1849T	ACH-000050	Myeloma	CCLE	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.3056
p.A1849T	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.3056
p.P909L	ACH-000269	Brain Cancer	CCLE	LATPITT	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7582
p.G585S	ACH-000436	Myeloma	CCLE	MAVTPGTT	DEG_SCF_FBW7_1	580:587	Mutation altering degron motif	0.5882
p.G585S	ACH-000436	Myeloma	CCLE	PGTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.5882
p.P1811Q	ACH-000573	Breast Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation altering degron motif	0.7035
p.P1811Q	MDA-MB-436	breast	COSMIC	KKENQ	DEG_APCC_KENBOX_2	1807:1811	Mutation altering degron motif	0.7035
p.G1832D	ACH-000986	Colon/Colorectal Cancer	CCLE	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1667
p.G1832D	HT-115	large intestine	COSMIC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.1667
p.E1834G	ACH-000988	Endometrial/Uterine Cancer	CCLE	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.2222
p.E1834G	MFE-319	endometrium	COSMIC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.2222
p.T948A	ACH-000999	Colon/Colorectal Cancer	CCLE	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.6028
p.T948A	SNU-1040	large intestine	COSMIC	LTTPTIT	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.6028
p.S1835F	ACH-002309	Sarcoma	CCLE	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.25
p.S1835F	SW684	soft tissue	COSMIC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation rewiring degron network	0.25
p.P1843L	LNCaP-Clone-FGC	prostate	COSMIC	SDDDLGTVPDY	DEG_COP1_1	1838:1848	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HCFC1

UniProt ID: P51610

Entrez ID: 3054

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HCFC1 in