DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SCF_FBW7_1

Location: 944:950

E3 ligase: FBXW7

DEGRON score: 0.7353

ASA_SCORE: 94.6571

COIL: 0.8924

CONS_SCORE: 0.4474

DSS_SCORE: 0.4109

HELIX: 0.0133

FCONS_SCORE: 0.9735

RIG_SCORE: 0.7753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M951I	TCGA-55-8089	LUAD	TCGA	LTTPTIT	DEG_SCF_FBW7_1	0.3056
p.M951I	DO23690	LUAD	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.3056
p.A941V	TCGA-A6-5665	COAD	TCGA	LTTPTIT	DEG_SCF_FBW7_1	0.25
p.A941V	DO9756	COAD	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.25
p.Q956K	TCGA-D3-A2J8	SKCM	TCGA	LTTPTIT	DEG_SCF_FBW7_1	0.1667
p.Q956K	DO37778	SKCM	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.1667
p.G943W	TCGA-FS-A1ZG	SKCM	TCGA	LTTPTIT	DEG_SCF_FBW7_1	0.3056
p.G943W	DO37523	SKCM	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.3056
p.T937M	DO233272	GACA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.1389
p.A940V	DO233867	GACA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.2222
p.T948N	DO229027	LICA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.5944
p.L944P	DO229098	LMS	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.6471
p.L944F	DO49203	PACA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.6981
p.P947L	DO229229	THCA	ICGC	LTTPTIT	DEG_SCF_FBW7_1	0.7582
p.V954L	SIDM02021	Esophageal Carcinoma	GDSC	LTTPTIT	DEG_SCF_FBW7_1	0.2222
p.T948A	ACH-000999	Colon/Colorectal Cancer	CCLE	LTTPTIT	DEG_SCF_FBW7_1	0.6028
p.T948A	SNU-1040	large_intestine	COSMIC	LTTPTIT	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51610	Host cell factor 1	DEG_SCF_FBW7_1	944:950	LTTPTIT	FBXW7	0.7353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons