DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_COP1_1

Location: 1838:1848

E3 ligase: COP1

DEGRON score: 0.9941

ASA_SCORE: 75.0818

COIL: 0.8592

CONS_SCORE: 0.5056

DSS_SCORE: 0.5312

HELIX: 0.0858

FCONS_SCORE: 1.0637

RIG_SCORE: 0.7654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1831Q	TCGA-CF-A8HX	BLCA	TCGA	SDDDLGTVPDY	DEG_COP1_1	0.1389
p.L1856P	TCGA-CV-A6K1	HNSC	TCGA	SDDDLGTVPDY	DEG_COP1_1	0.1111
p.L1856P	DO52078	HNSC	ICGC	SDDDLGTVPDY	DEG_COP1_1	0.1111
p.D1833G	TCGA-KK-A7AV	PRAD	TCGA	SDDDLGTVPDY	DEG_COP1_1	0.1944
p.D1833G	DO219301	PRAD	ICGC	SDDDLGTVPDY	DEG_COP1_1	0.1944
p.E1854Q	DO51555	KIRP	ICGC	SDDDLGTVPDY	DEG_COP1_1	0.1667
p.D1839E	DO229041	LICA	ICGC	SDDDLGTVPDY	DEG_COP1_1	0.5647
p.G1843D	DO220913	MELA	ICGC	SDDDLGTVPDY	DEG_COP1_1	0.6087
p.F1829L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SDDDLGTVPDY	DEG_COP1_1	0.0833
p.F1829L	ACH-000980	Lung Cancer	CCLE	SDDDLGTVPDY	DEG_COP1_1	0.0833
p.F1829L	NCI-H1155	lung	COSMIC	SDDDLGTVPDY	DEG_COP1_1	0.0833
p.P1837T	SIDM00780	Colorectal Carcinoma	GDSC	SDDDLGTVPDY	DEG_COP1_1	0.3056
p.A1849T	ACH-000050	Myeloma	CCLE	SDDDLGTVPDY	DEG_COP1_1	0.3056
p.A1849T	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	SDDDLGTVPDY	DEG_COP1_1	0.3056
p.G1832D	ACH-000986	Colon/Colorectal Cancer	CCLE	SDDDLGTVPDY	DEG_COP1_1	0.1667
p.G1832D	HT-115	large_intestine	COSMIC	SDDDLGTVPDY	DEG_COP1_1	0.1667
p.E1834G	ACH-000988	Endometrial/Uterine Cancer	CCLE	SDDDLGTVPDY	DEG_COP1_1	0.2222
p.E1834G	MFE-319	endometrium	COSMIC	SDDDLGTVPDY	DEG_COP1_1	0.2222
p.S1835F	ACH-002309	Sarcoma	CCLE	SDDDLGTVPDY	DEG_COP1_1	0.25
p.S1835F	SW684	soft_tissue	COSMIC	SDDDLGTVPDY	DEG_COP1_1	0.25
p.P1843L	LNCaP-Clone-FGC	prostate	COSMIC	SDDDLGTVPDY	DEG_COP1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51610	Host cell factor 1	DEG_COP1_1	1838:1848	SDDDLGTVPDY	COP1	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons