DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SPOP_SBC_1

Location: 1597:1601

E3 ligase: SPOP

DEGRON score: 0.9677

ASA_SCORE: 77.78

COIL: 0.7628

CONS_SCORE: 0.4635

DSS_SCORE: 0.4472

HELIX: 0.045

FCONS_SCORE: 0.9875

RIG_SCORE: 0.747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1593P	TCGA-98-A538	LUSC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2222
p.A1593P	DO219177	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.E1610D	TCGA-AP-A0LM	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.0833
p.E1610D	DO43306	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.A1597V	TCGA-CQ-6219	HNSC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.5825
p.E1594K	TCGA-EC-A24G	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.25
p.E1594K	DO40996	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.Q1589K	DO228976	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1111
p.E1610K	DO50970	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.E1610K	DO230934	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.Q1603K	DO45390	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2778
p.L1587R	DO220866	MELA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.D1592N	DO37750	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.A1590T	DO43891	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.T1605M	DO42673	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.G1606W	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.G1597E	ACH-000001	Ovarian Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.7199
p.G1597E	OVCAR-3	ovary	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons