DegronMD

Uniprot ID: P49840

Source protein: Glycogen synthase kinase-3 alpha

Source gene: GSK3A

Class: DEG_SPOP_SBC_1

Location: 449:453

E3 ligase: SPOP

DEGRON score: 0.9893

ASA_SCORE: 74.5

COIL: 0.9044

CONS_SCORE: 0.1929

DSS_SCORE: 0.6007

HELIX: 0.0336

FCONS_SCORE: 0.5656

RIG_SCORE: 0.632

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T452N	DO229009	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7055
p.L454I	SIDM01113	Other Sarcomas	GDSC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.L454I	ACH-000939	Sarcoma	CCLE	AGTTT	DEG_SPOP_SBC_1	0.3056
p.L454I	SK-UT-1	soft_tissue	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.3056

Drug responses associated with GSK3A mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00533	PAAD\|pancreas	p.G325W (No)	GDSC	CHIR-99021	36.1153
SIDM00533	PAAD\|pancreas	p.G325W (No)	GDSC	SB216763	157.5582
SIDM00533	PAAD\|pancreas	p.G325W (No)	GDSC	CHIR-99021	39.5496
SIDM00839	COREAD\|large_intestine	p.G13fs*2 (No)	GDSC	CHIR-99021	5.037
SIDM00839	COREAD\|large_intestine	p.G13fs*2 (No)	GDSC	SB216763	12.4859
SIDM00839	COREAD\|large_intestine	p.G13fs*2 (No)	GDSC	CHIR-99021	23.5989
SIDM00839	COREAD\|large_intestine	p.G13fs*2 (No)	GDSC	SB216763	50.56
SIDM00325	ESCA\|oesophagus	p.I235M (No)	GDSC	CHIR-99021	21.8539
SIDM00325	ESCA\|oesophagus	p.I235M (No)	GDSC	SB216763	142.369
SIDM00325	ESCA\|oesophagus	p.I235M (No)	GDSC	CHIR-99021	102.9934
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R230H (No)	GDSC	CHIR-99021	4.2996
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R230H (No)	GDSC	SB216763	22.9938
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R230H (No)	GDSC	CHIR-99021	5.4189
SIDM00826	COREAD\|large_intestine	p.F292L (No)	GDSC	CHIR-99021	5.6011
SIDM00826	COREAD\|large_intestine	p.F292L (No)	GDSC	SB216763	58.6902
SIDM00826	COREAD\|large_intestine	p.F292L (No)	GDSC	CHIR-99021	90.4119
SIDM00826	COREAD\|large_intestine	p.F292L (No)	GDSC	SB216763	23.223
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.D255E (No)	GDSC	CHIR-99021	50.0017
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.D255E (No)	GDSC	SB216763	196.9607
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.D255E (No)	GDSC	CHIR-99021	109.7139
SIDM00499	PRAD\|prostate	p.K186delK (No)	GDSC	CHIR-99021	37.0537
SIDM00499	PRAD\|prostate	p.K186delK (No)	GDSC	SB216763	159.546
SIDM00499	PRAD\|prostate	p.K186delK (No)	GDSC	CHIR-99021	25.3759
SIDM00516	SKCM\|melanoma	p.L379F (No)	GDSC	CHIR-99021	13.5512
SIDM00516	SKCM\|melanoma	p.L379F (No)	GDSC	SB216763	74.9929
SIDM00516	SKCM\|melanoma	p.L379F (No)	GDSC	CHIR-99021	127.0411
SIDM00112	KIRC\|kidney	p.A378T (No)	GDSC	CHIR-99021	18.8907
SIDM00112	KIRC\|kidney	p.A378T (No)	GDSC	SB216763	114.0497
SIDM00112	KIRC\|kidney	p.A378T (No)	GDSC	CHIR-99021	2.4743
SIDM00216	COREAD\|large_intestine	p.R272* (No)	GDSC	SB216763	57.37
SIDM00216	COREAD\|large_intestine	p.V133M (No)	GDSC	SB216763	57.37
SIDM00596	UCEC\|endometrium	p.R165H (No)	GDSC	CHIR-99021	16.1597
SIDM00596	UCEC\|endometrium	p.R165H (No)	GDSC	SB216763	59.065
SIDM00596	UCEC\|endometrium	p.R165H (No)	GDSC	CHIR-99021	47.1475
SIDM01084	UNCLASSIFIED\|osteosarcoma	p.T201K (No)	GDSC	CHIR-99021	42.8405
SIDM01084	UNCLASSIFIED\|osteosarcoma	p.T201K (No)	GDSC	SB216763	188.3581
SIDM01084	UNCLASSIFIED\|osteosarcoma	p.T201K (No)	GDSC	CHIR-99021	363.777
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.S324G (No)	GDSC	CHIR-99021	17.9791
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.S324G (No)	GDSC	SB216763	19.0186
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.S324G (No)	GDSC	CHIR-99021	34.0234
SIDM00789	COREAD\|large_intestine	p.A118D (No)	GDSC	CHIR-99021	19.8132
SIDM00789	COREAD\|large_intestine	p.A118D (No)	GDSC	SB216763	160.3627
SIDM00789	COREAD\|large_intestine	p.A118D (No)	GDSC	CHIR-99021	141.9781
SIDM00789	COREAD\|large_intestine	p.A118D (No)	GDSC	SB216763	92.626
SIDM00142	UCEC\|endometrium	p.N350fs*11 (No)	GDSC	CHIR-99021	43.3299
SIDM00142	UCEC\|endometrium	p.N350fs*11 (No)	GDSC	SB216763	39.2222
SIDM00142	UCEC\|endometrium	p.N350fs*11 (No)	GDSC	CHIR-99021	155.2844
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.L454I (Yes)	GDSC	CHIR-99021	9.3856
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.L454I (Yes)	GDSC	SB216763	83.7828
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.L454I (Yes)	GDSC	CHIR-99021	21.4215
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.V104I (No)	GDSC	CHIR-99021	9.3856
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.V104I (No)	GDSC	SB216763	83.7828
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.V104I (No)	GDSC	CHIR-99021	21.4215
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.Q358* (No)	GDSC	CHIR-99021	8.1835
SIDM00118	COREAD\|large_intestine	p.F130V (No)	GDSC	CHIR-99021	13.1037
SIDM00118	COREAD\|large_intestine	p.F130V (No)	GDSC	SB216763	113.6379
SIDM00118	COREAD\|large_intestine	p.F130V (No)	GDSC	CHIR-99021	88.187
SIDM00118	COREAD\|large_intestine	p.F130V (No)	GDSC	SB216763	209.26

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGTTT

Degron related mutations and impact score

Drug responses associated with GSK3A mutations

All proteins holding degron of AGTTT