DegronMD

Uniprot ID: Q9UJD0

Source protein: Regulating synaptic membrane exocytosis protein 3

Source gene: RIMS3

Class: DEG_SPOP_SBC_1

Location: 37:41

E3 ligase: SPOP

DEGRON score: 0.9961

ASA_SCORE: 78.12

COIL: 0.8744

CONS_SCORE: 0.4991

DSS_SCORE: 0.569

HELIX: 0.099

FCONS_SCORE: 1.0405

RIG_SCORE: 0.6782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A42T	TCGA-32-1977	GBM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.A42T	TCGA-AA-A010	COAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.A42T	TCGA-CN-4730	HNSC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.A42T	DO12076	GBM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.A42T	DO14234	HNSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.R45W	TCGA-A2-A4S1	BRCA	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2222
p.R45W	DO44216	BRCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.G38W	TCGA-D3-A3CB	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.6714
p.G38W	DO47386	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.6714
p.Q31K	TCGA-D3-A3CE	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1667
p.Q31K	DO37405	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.G29R	DO233270	GACA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1111
p.A33D	DO229018	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.G34W	SIDM00664	Pancreatic Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.25
p.G34W	ACH-000178	Pancreatic Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.25
p.A37V	SIDM00142	Endometrial Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.5825
p.A37V	ACH-000864	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.5825
p.A37V	COLO-684	endometrium	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.5825
p.G34R	ACH-000918	Leukemia	CCLE	AGTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons