DegronMD

Uniprot ID: Q08708

Source protein: CMRF35-like molecule 6

Source gene: CD300C

Class: DEG_SPOP_SBC_1

Location: 134:138

E3 ligase: SPOP

DEGRON score: 0.9394

ASA_SCORE: 63.2

COIL: 0.876

CONS_SCORE: 0.278

DSS_SCORE: 0.5204

HELIX: 0.044

FCONS_SCORE: 0.7038

RIG_SCORE: 0.675

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A139V	TCGA-AA-3977	COAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.A139V	DO8730	COAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.P142S	TCGA-BF-AAP2	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2222
p.P142S	DO219466	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.P133Q	TCGA-BJ-A2N8	THCA	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.P133Q	DO48068	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.P133L	TCGA-BR-8078	STAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.P133L	DO222815	BTCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.P133L	DO38288	STAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.E128Q	TCGA-C5-A7X3	CESC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1667
p.E128Q	DO49893	CESC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.P142L	TCGA-DA-A3F8	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2222
p.P142L	DO37418	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.S140F	TCGA-EB-A5UN	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2778
p.S140F	DO47267	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2778
p.A134V	TCGA-EI-6882	READ	TCGA	AGTTT	DEG_SPOP_SBC_1	0.5825
p.A134V	DO36531	READ	ICGC	AGTTT	DEG_SPOP_SBC_1	0.5825
p.A139T	TCGA-FI-A2D5	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.A139T	DO41331	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.S141R	TCGA-WB-A817	PCPG	TCGA	AGTTT	DEG_SPOP_SBC_1	0.25
p.S141R	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.25
p.S141R	ACH-000858	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.25
p.S141R	KNS-62	lung	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.25
p.A139D	DO229019	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.I124V	DO229253	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.S141G	DO229227	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.V127A	SIDM00571	Pancreatic Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.V127A	ACH-000108	Pancreatic Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.1389
p.V127A	KP-3	pancreas	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.Q143H	SIDM00118	Colorectal Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.Q143H	ACH-001081	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.1944
p.Q143H	HCC2998	large_intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGTTT

Degron related mutations and impact score

Drug responses associated with CD300C mutations

All proteins holding degron of AGTTT