DegronMD - Q03828(EVX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A145E	TCGA-86-8073	LUAD	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1944
p.A145E	TCGA-86-8073	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.A145E	DO23624	LUAD	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1944
p.A145E	DO23624	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.S160P	TCGA-94-8490	LUSC	TCGA	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.S160P	DO52021	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.R126C	TCGA-BA-5152	HNSC	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0556
p.R126C	DO14393	HNSC	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0556
p.S149L	TCGA-BR-A4QL	STAD	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.S149L	TCGA-BR-A4QL	STAD	TCGA	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2778
p.S149L	DO38723	STAD	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.S149L	DO38723	STAD	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2778
p.T154M	TCGA-CV-7236	HNSC	TCGA	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7423
p.T154M	DO15230	HNSC	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7423
p.G132D	TCGA-D1-A103	UCEC	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.2222
p.G132D	DO42312	UCEC	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.2222
p.P128L	TCGA-EE-A2MS	SKCM	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1111
p.P128L	TCGA-ER-A19F	SKCM	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1111
p.P128L	DO37679	SKCM	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1111
p.P128L	DO37567	SKCM	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1111
p.A133T	TCGA-F1-6177	STAD	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.A133T	TCGA-Q1-A6DV	CESC	TCGA	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.A133T	DO44334	CESC	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.A133T	DO38727	STAD	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.G143V	DO52626	BOCA	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.G143V	DO52626	BOCA	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1111
p.G130V	DO228483	BRCA	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1667
p.R126H	DO233649	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0556
p.R126H	DO233867	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0556
p.A151V	DO228917	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.5825
p.L165M	DO228978	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.S164I	DO231096	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0833
p.P128S	DO222875	MELA	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1111
p.P128S	ACH-001567	Skin Cancer	CCLE	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1111
p.E138K	DO37432	SKCM	ICGC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.7022
p.E138K	ACH-001970	Metastasis	CCLE	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.7022
p.A133V	SIDM01278	Colorectal Carcinoma	GDSC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.G141A	SIDM00845	Burkitt's Lymphoma	GDSC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.3056
p.G141A	SIDM00845	Burkitt's Lymphoma	GDSC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.S160L	SIDM00496	Thyroid Gland Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.S160L	ACH-001350	Thyroid Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.S160L	HTC-C3	thyroid	COSMIC	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.G132R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.2222
p.A150P	ACH-000431	Lung Cancer	CCLE	LKENN	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0556
p.A150P	ACH-000431	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVX2

UniProt ID: Q03828

Entrez ID: 344191

Protein name: Homeobox even-skipped homolog protein 2 (EVX-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVX2 in