DegronMD

Uniprot ID: Q03828

Source protein: Homeobox even-skipped homolog protein 2

Source gene: EVX2

Class: DEG_APCC_KENBOX_2

Location: 136:140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9747

ASA_SCORE: 104.56

COIL: 0.6952

CONS_SCORE: 0.4976

DSS_SCORE: 0.4927

HELIX: 0.2702

FCONS_SCORE: 1.1726

RIG_SCORE: 0.7089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A145E	TCGA-86-8073	LUAD	TCGA	LKENN	DEG_APCC_KENBOX_2	0.1944
p.A145E	DO23624	LUAD	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1944
p.R126C	TCGA-BA-5152	HNSC	TCGA	LKENN	DEG_APCC_KENBOX_2	0.0556
p.R126C	DO14393	HNSC	ICGC	LKENN	DEG_APCC_KENBOX_2	0.0556
p.S149L	TCGA-BR-A4QL	STAD	TCGA	LKENN	DEG_APCC_KENBOX_2	0.0833
p.S149L	DO38723	STAD	ICGC	LKENN	DEG_APCC_KENBOX_2	0.0833
p.G132D	TCGA-D1-A103	UCEC	TCGA	LKENN	DEG_APCC_KENBOX_2	0.2222
p.G132D	DO42312	UCEC	ICGC	LKENN	DEG_APCC_KENBOX_2	0.2222
p.P128L	TCGA-EE-A2MS	SKCM	TCGA	LKENN	DEG_APCC_KENBOX_2	0.1111
p.P128L	TCGA-ER-A19F	SKCM	TCGA	LKENN	DEG_APCC_KENBOX_2	0.1111
p.P128L	DO37679	SKCM	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1111
p.P128L	DO37567	SKCM	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1111
p.A133T	TCGA-F1-6177	STAD	TCGA	LKENN	DEG_APCC_KENBOX_2	0.25
p.A133T	TCGA-Q1-A6DV	CESC	TCGA	LKENN	DEG_APCC_KENBOX_2	0.25
p.A133T	DO44334	CESC	ICGC	LKENN	DEG_APCC_KENBOX_2	0.25
p.A133T	DO38727	STAD	ICGC	LKENN	DEG_APCC_KENBOX_2	0.25
p.G143V	DO52626	BOCA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.25
p.G130V	DO228483	BRCA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1667
p.R126H	DO233649	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.0556
p.R126H	DO233867	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.0556
p.P128S	DO222875	MELA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1111
p.P128S	ACH-001567	Skin Cancer	CCLE	LKENN	DEG_APCC_KENBOX_2	0.1111
p.E138K	DO37432	SKCM	ICGC	LKENN	DEG_APCC_KENBOX_2	0.7022
p.E138K	ACH-001970	Metastasis	CCLE	LKENN	DEG_APCC_KENBOX_2	0.7022
p.A133V	SIDM01278	Colorectal Carcinoma	GDSC	LKENN	DEG_APCC_KENBOX_2	0.25
p.G141A	SIDM00845	Burkitt's Lymphoma	GDSC	LKENN	DEG_APCC_KENBOX_2	0.3056
p.G132R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LKENN	DEG_APCC_KENBOX_2	0.2222
p.A150P	ACH-000431	Lung Cancer	CCLE	LKENN	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30622	CAP-Gly domain-containing linker protein 1	DEG_APCC_KENBOX_2	1126:1130	LKENN	APC,CDC20,FZR1	0.7892	More...
Q9H4Z3	mRNA	DEG_APCC_KENBOX_2	383:387	LKENN	APC,CDC20,FZR1	0.7225	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_APCC_KENBOX_2	136:140	LKENN	APC,CDC20,FZR1	0.9747	More...
Q8N4H0	Spermatogenesis associated 6-like protein	DEG_APCC_KENBOX_2	170:174	LKENN	APC,CDC20,FZR1	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKENN

Degron related mutations and impact score

Drug responses associated with EVX2 mutations

All proteins holding degron of LKENN