DegronMD - Q8N4H0(SPATA6L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R183M	TCGA-AP-A1DK	UCEC	TCGA	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.0833
p.P171L	TCGA-EE-A20C	SKCM	TCGA	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation altering degron motif	0.7582
p.P171L	DO222775	MELA	ICGC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation altering degron motif	0.7582
p.V166M	TCGA-F7-A61V	HNSC	TCGA	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.2222
p.L181F	TCGA-JW-A5VL	CESC	TCGA	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1389
p.T165S	DO233724	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1944
p.T165N	DO229018	LICA	ICGC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1944
p.A169E	DO229026	LICA	ICGC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.3056
p.P162S	DO229459	SKCA	ICGC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1111
p.G181C	DO223282	UCEC	ICGC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1389
p.R182W	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1111
p.R182W	ACH-002059	Leukemia	CCLE	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1111
p.R182W	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1111
p.S163T	NCI-H345	lung	COSMIC	LKENN	DEG_APCC_KENBOX_2	170:174	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons