DegronMD

Uniprot ID: Q8N4H0

Source protein: Spermatogenesis associated 6-like protein

Source gene: SPATA6L

Class: DEG_APCC_KENBOX_2

Location: 170:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9657

ASA_SCORE: 106.42

COIL: 0.5434

CONS_SCORE: 0.4013

DSS_SCORE: 0.5019

HELIX: 0.4516

FCONS_SCORE: 1.0683

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R183M	TCGA-AP-A1DK	UCEC	TCGA	LKENN	DEG_APCC_KENBOX_2	0.0833
p.P171L	TCGA-EE-A20C	SKCM	TCGA	LKENN	DEG_APCC_KENBOX_2	0.7582
p.P171L	DO222775	MELA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.7582
p.V166M	TCGA-F7-A61V	HNSC	TCGA	LKENN	DEG_APCC_KENBOX_2	0.2222
p.L181F	TCGA-JW-A5VL	CESC	TCGA	LKENN	DEG_APCC_KENBOX_2	0.1389
p.T165S	DO233724	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1944
p.T165N	DO229018	LICA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1944
p.A169E	DO229026	LICA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.3056
p.P162S	DO229459	SKCA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1111
p.G181C	DO223282	UCEC	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1389
p.R182W	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LKENN	DEG_APCC_KENBOX_2	0.1111
p.R182W	ACH-002059	Leukemia	CCLE	LKENN	DEG_APCC_KENBOX_2	0.1111
p.R182W	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LKENN	DEG_APCC_KENBOX_2	0.1111
p.S163T	NCI-H345	lung	COSMIC	LKENN	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30622	CAP-Gly domain-containing linker protein 1	DEG_APCC_KENBOX_2	1126:1130	LKENN	APC,CDC20,FZR1	0.7892	More...
Q9H4Z3	mRNA	DEG_APCC_KENBOX_2	383:387	LKENN	APC,CDC20,FZR1	0.7225	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_APCC_KENBOX_2	136:140	LKENN	APC,CDC20,FZR1	0.9747	More...
Q8N4H0	Spermatogenesis associated 6-like protein	DEG_APCC_KENBOX_2	170:174	LKENN	APC,CDC20,FZR1	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons