DegronMD - Q9H4Z3(PCIF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H379Q	TCGA-23-2084	OV	TCGA	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.2222
p.H379Q	DO30310	OV	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.2222
p.R113W	TCGA-D7-A4YV	STAD	TCGA	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.1667
p.R113W	DO47777	STAD	ICGC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.1667
p.R376Q	TCGA-FD-A3SN	BLCA	TCGA	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1389
p.R376Q	DO490	BLCA	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1389
p.R376Q	DO222846	COCA	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1389
p.A394V	TCGA-IB-7651	PAAD	TCGA	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1389
p.A394V	DO46657	PAAD	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1389
p.A106T	TCGA-PG-A917	UCEC	TCGA	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation altering degron motif	0.6028
p.A106T	DO52424	UCEC	ICGC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation altering degron motif	0.6028
p.A106T	SIDM01617	Endometrial Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation altering degron motif	0.6028
p.A106T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation altering degron motif	0.6028
p.P110H	DO227987	COCA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.25
p.K373R	DO229013	COCA	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation substituting flanking lysine	0.1667
p.N108K	DO217814	GACA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.3056
p.R374W	DO233941	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.0833
p.D97Y	DO229031	LICA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.25
p.V392G	DO52352	LUSC	ICGC	LKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1944
p.E117Q	DO222810	MELA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.0556
p.R113Q	SIDM00441	Acute Myeloid Leukemia	GDSC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.1667
p.R113Q	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.1667
p.S116P	SIDM00878	Breast Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation blocking phosphorylation signal	0.5278
p.S116P	SIDM01387	Small Cell Lung Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation blocking phosphorylation signal	0.5278
p.T103A	SIDM00014	Colorectal Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation altering degron motif	0.7139
p.T103A	LIM1215	large intestine	COSMIC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation altering degron motif	0.7139
p.D97E	ACH-002287	Colon/Colorectal Cancer	CCLE	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.25
p.D97E	NCI-H630	large intestine	COSMIC	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.25
p.A91V	ACH-002372	Non-Cancerous	CCLE	LVETPPAE	DEG_SCF_FBW7_2	100:107	Mutation rewiring degron network	0.0833

Kaplan plot for PCIF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCIF1

UniProt ID: Q9H4Z3

Entrez ID: 63935

Protein name: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCIF1 in