DegronMD

Uniprot ID: Q9H4Z3

Source protein: mRNA

Source gene: PCIF1

Class: DEG_SCF_FBW7_2

Location: 100:107

E3 ligase: FBXW7

DEGRON score: 0.8252

ASA_SCORE: 92.05

COIL: 0.8936

CONS_SCORE: 0.3322

DSS_SCORE: 0.7527

HELIX: 0.072

FCONS_SCORE: 1.0658

RIG_SCORE: 0.6325

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R113W	TCGA-D7-A4YV	STAD	TCGA	LVETPPAE	DEG_SCF_FBW7_2	0.1667
p.R113W	DO47777	STAD	ICGC	LVETPPAE	DEG_SCF_FBW7_2	0.1667
p.A106T	TCGA-PG-A917	UCEC	TCGA	LVETPPAE	DEG_SCF_FBW7_2	0.6028
p.A106T	DO52424	UCEC	ICGC	LVETPPAE	DEG_SCF_FBW7_2	0.6028
p.A106T	SIDM01617	Endometrial Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	0.6028
p.A106T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LVETPPAE	DEG_SCF_FBW7_2	0.6028
p.P110H	DO227987	COCA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	0.25
p.N108K	DO217814	GACA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	0.3056
p.D97Y	DO229031	LICA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	0.25
p.E117Q	DO222810	MELA	ICGC	LVETPPAE	DEG_SCF_FBW7_2	0.0556
p.R113Q	SIDM00441	Acute Myeloid Leukemia	GDSC	LVETPPAE	DEG_SCF_FBW7_2	0.1667
p.R113Q	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	0.1667
p.S116P	SIDM00878	Breast Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	0.5278
p.S116P	SIDM01387	Small Cell Lung Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	0.5278
p.T103A	SIDM00014	Colorectal Carcinoma	GDSC	LVETPPAE	DEG_SCF_FBW7_2	0.7139
p.T103A	LIM1215	large_intestine	COSMIC	LVETPPAE	DEG_SCF_FBW7_2	0.7139
p.D97E	ACH-002287	Colon/Colorectal Cancer	CCLE	LVETPPAE	DEG_SCF_FBW7_2	0.25
p.D97E	NCI-H630	large_intestine	COSMIC	LVETPPAE	DEG_SCF_FBW7_2	0.25
p.A91V	ACH-002372	Non-Cancerous	CCLE	LVETPPAE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4Z3	mRNA	DEG_SCF_FBW7_2	100:107	LVETPPAE	FBXW7	0.8252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons