DegronMD

Uniprot ID: Q9H4Z3

Source protein: mRNA

Source gene: PCIF1

Class: DEG_APCC_KENBOX_2

Location: 383:387

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7225

ASA_SCORE: 96.84

COIL: 0.4602

CONS_SCORE: 0.6202

DSS_SCORE: 0.1843

HELIX: 0.5378

FCONS_SCORE: 1.4589

RIG_SCORE: 0.8004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H379Q	TCGA-23-2084	OV	TCGA	LKENN	DEG_APCC_KENBOX_2	0.2222
p.H379Q	DO30310	OV	ICGC	LKENN	DEG_APCC_KENBOX_2	0.2222
p.R376Q	TCGA-FD-A3SN	BLCA	TCGA	LKENN	DEG_APCC_KENBOX_2	0.1389
p.R376Q	DO490	BLCA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1389
p.R376Q	DO222846	COCA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1389
p.A394V	TCGA-IB-7651	PAAD	TCGA	LKENN	DEG_APCC_KENBOX_2	0.1389
p.A394V	DO46657	PAAD	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1389
p.K373R	DO229013	COCA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1667
p.R374W	DO233941	GACA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.0833
p.V392G	DO52352	LUSC	ICGC	LKENN	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30622	CAP-Gly domain-containing linker protein 1	DEG_APCC_KENBOX_2	1126:1130	LKENN	APC,CDC20,FZR1	0.7892	More...
Q9H4Z3	mRNA	DEG_APCC_KENBOX_2	383:387	LKENN	APC,CDC20,FZR1	0.7225	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_APCC_KENBOX_2	136:140	LKENN	APC,CDC20,FZR1	0.9747	More...
Q8N4H0	Spermatogenesis associated 6-like protein	DEG_APCC_KENBOX_2	170:174	LKENN	APC,CDC20,FZR1	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons