DegronMD - P30622(CLIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S186N	TCGA-61-2110	OV	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.818
p.S186N	DO27979	OV	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.818
p.V33L	TCGA-78-8662	LUAD	TCGA	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation altering degron motif	0.5654
p.V33L	DO45346	LUAD	ICGC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation altering degron motif	0.5654
p.K190T	TCGA-AA-A00N	COAD	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation substituting flanking lysine	0.3333
p.K190T	DO9876	COAD	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation substituting flanking lysine	0.3333
p.E178D	TCGA-AP-A051	UCEC	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.3056
p.E178D	DO42673	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.3056
p.P174T	TCGA-BG-A220	UCEC	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.P174T	DO41784	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.P184L	TCGA-CK-4951	COAD	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6471
p.P184L	DO10582	COAD	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6471
p.E178K	TCGA-D3-A1QA	SKCM	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.3056
p.E178K	DO47469	SKCM	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.3056
p.S193N	TCGA-DU-6407	LGG	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.5833
p.S193N	DO22295	LGG	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.5833
p.P184S	TCGA-EB-A41A	SKCM	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.5641
p.P184S	DO37429	SKCM	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.5641
p.L1123W	TCGA-HU-A4GF	STAD	TCGA	LKENN	DEG_APCC_KENBOX_2	1126:1130	Mutation rewiring degron network	0.25
p.P184A	TCGA-ZF-AA5P	BLCA	TCGA	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6392
p.P184A	DO219103	BLCA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6392
p.P184A	SIDM00528	Breast Carcinoma	GDSC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6392
p.P184A	ACH-000934	Breast Cancer	CCLE	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6392
p.P184A	MDA-MB-361	breast	COSMIC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6392
p.E189V	DO52483	COCA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.6944
p.K183E	DO18332	KIRC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.7022
p.S29R	DO229027	LICA	ICGC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation altering degron motif	0.7427
p.T25K	DO229027	LICA	ICGC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation altering degron motif	0.7306
p.D190E	DO229036	LICA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation substituting flanking lysine	0.3333
p.A175E	DO229036	LICA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2222
p.T1116N	DO229041	LICA	ICGC	LKENN	DEG_APCC_KENBOX_2	1126:1130	Mutation rewiring degron network	0.0556
p.A24V	DO38431	STAD	ICGC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.3056
p.K183R	DO42568	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.7237
p.L184F	DO43755	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6981
p.S39N	SIDM00333	Endometrial Carcinoma	GDSC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.1667
p.S39N	ACH-000988	Endometrial/Uterine Cancer	CCLE	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.1667
p.S39N	MFE-319	endometrium	COSMIC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.1667
p.G35R	ACH-000636	Leukemia	CCLE	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.2778
p.G35R	ACH-001203	Lymphoma	CCLE	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.2778
p.G35R	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.2778
p.G35R	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.2778
p.K15T	ACH-000997	Colon/Colorectal Cancer	CCLE	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.0556
p.K15T	ACH-001061	Colon/Colorectal Cancer	CCLE	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.0556
p.A1125T	KMH-2	thyroid	COSMIC	LKENN	DEG_APCC_KENBOX_2	1126:1130	Mutation rewiring degron network	0.3056
p.L19I	PF-382	haematopoietic and lymphoid tissue	COSMIC	TPTAVVAPV	DEG_SIAH_1	25:33	Mutation rewiring degron network	0.1667
p.T195A	Farage	haematopoietic and lymphoid tissue	COSMIC	PSATPPIS	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.5278
p.A1128V	TOV-21G	ovary	COSMIC	LKENN	DEG_APCC_KENBOX_2	1126:1130	Mutation altering degron motif	0.6936

Kaplan plot for CLIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLIP1

UniProt ID: P30622

Entrez ID: 6249

Protein name: CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLIP1 in