DegronMD

Uniprot ID: P30622

Source protein: CAP-Gly domain-containing linker protein 1

Source gene: CLIP1

Class: DEG_SCF_FBW7_1

Location: 179:186

E3 ligase: FBXW7

DEGRON score: 0.9792

ASA_SCORE: 84.4625

COIL: 0.8975

CONS_SCORE: 0.4064

DSS_SCORE: 0.6842

HELIX: 0.0715

FCONS_SCORE: 1.0945

RIG_SCORE: 0.6069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S186N	TCGA-61-2110	OV	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.818
p.S186N	DO27979	OV	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.818
p.K190T	TCGA-AA-A00N	COAD	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.3333
p.K190T	DO9876	COAD	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.3333
p.E178D	TCGA-AP-A051	UCEC	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.3056
p.E178D	DO42673	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.3056
p.P174T	TCGA-BG-A220	UCEC	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.1944
p.P174T	DO41784	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.1944
p.P184L	TCGA-CK-4951	COAD	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.6471
p.P184L	DO10582	COAD	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.6471
p.E178K	TCGA-D3-A1QA	SKCM	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.3056
p.E178K	DO47469	SKCM	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.3056
p.S193N	TCGA-DU-6407	LGG	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.5833
p.S193N	DO22295	LGG	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.5833
p.P184S	TCGA-EB-A41A	SKCM	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.5641
p.P184S	DO37429	SKCM	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.5641
p.P184A	TCGA-ZF-AA5P	BLCA	TCGA	PSATPPIS	DEG_SCF_FBW7_1	0.6392
p.P184A	DO219103	BLCA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.6392
p.P184A	SIDM00528	Breast Carcinoma	GDSC	PSATPPIS	DEG_SCF_FBW7_1	0.6392
p.P184A	ACH-000934	Breast Cancer	CCLE	PSATPPIS	DEG_SCF_FBW7_1	0.6392
p.P184A	MDA-MB-361	breast	COSMIC	PSATPPIS	DEG_SCF_FBW7_1	0.6392
p.E189V	DO52483	COCA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.6944
p.K183E	DO18332	KIRC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.7022
p.D190E	DO229036	LICA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.3333
p.A175E	DO229036	LICA	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.2222
p.K183R	DO42568	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.7237
p.L184F	DO43755	UCEC	ICGC	PSATPPIS	DEG_SCF_FBW7_1	0.6981
p.T195A	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PSATPPIS	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30622	CAP-Gly domain-containing linker protein 1	DEG_SCF_FBW7_1	179:186	PSATPPIS	FBXW7	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSATPPIS

Degron related mutations and impact score

Drug responses associated with CLIP1 mutations

All proteins holding degron of PSATPPIS