DegronMD

Uniprot ID: P30622

Source protein: CAP-Gly domain-containing linker protein 1

Source gene: CLIP1

Class: DEG_SIAH_1

Location: 25:33

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9975

ASA_SCORE: 87.9444

COIL: 0.9172

CONS_SCORE: 0.2519

DSS_SCORE: 0.4538

HELIX: 0.058

FCONS_SCORE: 1.0363

RIG_SCORE: 0.7685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V33L	TCGA-78-8662	LUAD	TCGA	TPTAVVAPV	DEG_SIAH_1	0.5654
p.V33L	DO45346	LUAD	ICGC	TPTAVVAPV	DEG_SIAH_1	0.5654
p.S29R	DO229027	LICA	ICGC	TPTAVVAPV	DEG_SIAH_1	0.7427
p.T25K	DO229027	LICA	ICGC	TPTAVVAPV	DEG_SIAH_1	0.7306
p.A24V	DO38431	STAD	ICGC	TPTAVVAPV	DEG_SIAH_1	0.3056
p.S39N	SIDM00333	Endometrial Carcinoma	GDSC	TPTAVVAPV	DEG_SIAH_1	0.1667
p.S39N	ACH-000988	Endometrial/Uterine Cancer	CCLE	TPTAVVAPV	DEG_SIAH_1	0.1667
p.S39N	MFE-319	endometrium	COSMIC	TPTAVVAPV	DEG_SIAH_1	0.1667
p.G35R	ACH-000636	Leukemia	CCLE	TPTAVVAPV	DEG_SIAH_1	0.2778
p.G35R	ACH-001203	Lymphoma	CCLE	TPTAVVAPV	DEG_SIAH_1	0.2778
p.G35R	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	TPTAVVAPV	DEG_SIAH_1	0.2778
p.G35R	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	TPTAVVAPV	DEG_SIAH_1	0.2778
p.K15T	ACH-000997	Colon/Colorectal Cancer	CCLE	TPTAVVAPV	DEG_SIAH_1	0.0556
p.K15T	ACH-001061	Colon/Colorectal Cancer	CCLE	TPTAVVAPV	DEG_SIAH_1	0.0556
p.L19I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	TPTAVVAPV	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30622	CAP-Gly domain-containing linker protein 1	DEG_SIAH_1	25:33	TPTAVVAPV	SIAH1,SIAH2,SIAH3	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons