DegronMD

Uniprot ID: P30622

Source protein: CAP-Gly domain-containing linker protein 1

Source gene: CLIP1

Class: DEG_APCC_KENBOX_2

Location: 1126:1130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7892

ASA_SCORE: 104.46

COIL: 0.1098

CONS_SCORE: 0.4448

DSS_SCORE: 0.4445

HELIX: 0.8894

FCONS_SCORE: 1.1914

RIG_SCORE: 0.7658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1123W	TCGA-HU-A4GF	STAD	TCGA	LKENN	DEG_APCC_KENBOX_2	0.25
p.T1116N	DO229041	LICA	ICGC	LKENN	DEG_APCC_KENBOX_2	0.0556
p.A1125T	KMH-2	thyroid	COSMIC	LKENN	DEG_APCC_KENBOX_2	0.3056
p.A1128V	TOV-21G	ovary	COSMIC	LKENN	DEG_APCC_KENBOX_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30622	CAP-Gly domain-containing linker protein 1	DEG_APCC_KENBOX_2	1126:1130	LKENN	APC,CDC20,FZR1	0.7892	More...
Q9H4Z3	mRNA	DEG_APCC_KENBOX_2	383:387	LKENN	APC,CDC20,FZR1	0.7225	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_APCC_KENBOX_2	136:140	LKENN	APC,CDC20,FZR1	0.9747	More...
Q8N4H0	Spermatogenesis associated 6-like protein	DEG_APCC_KENBOX_2	170:174	LKENN	APC,CDC20,FZR1	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons